Progress of the Relationship between DNA Methylation and Type 2 Diabetes

doi:10.3969/j.issn.1673-5765.2022.11.005

Abstract

Abstract: Type 2 diabetes is one of the most common risk factors for ischemic stroke, and its pathogenesis has not yet been elucidated. Several studies in recent years showed that epigenetics can explain part risks of type 2 diabetes. Epigenetics includes DNA methylation, histone modification, chromatin remodeling, non-coding RNA, etc. Among them, DNA methylation is an important mechnism, and is also the earliest and most widely studied mechanism. This article introduced the research progress of DNA methylation in pathophysiological mechanism, environmental factors, risk factors and complications related to type 2 diabetes, discussed the clinical prospect of DNA methylation for type 2 diabetes prediction and diagnosis, and proposed the possibility of promoting primary and secondary prevention of ischemic stroke by studying DNA methylation in depth.

Key words: DNA methylation; Type 2 diabetes mellitus; Ischemic stroke

摘要： 2型糖尿病是缺血性卒中最常见的危险因素之一，其发生、发展的机制尚未阐明。近年来多项研究发现，表观遗传学可以解释部分2型糖尿病相关风险。表观遗传学包括DNA甲基化、组蛋白修饰、染色质重塑、非编码RNA等，其中DNA甲基化是表观遗传学的重要组成部分，也是研究最早最广泛的机制。本文介绍了DNA甲基化在2型糖尿病相关的病理生理机制、环境因素、危险因素及并发症等方面的研究进展，探讨了DNA甲基化用于2型糖尿病预测及诊疗的临床前景，提出了通过研究DNA甲基化促进缺血性卒中一级及二级预防的可能。

关键词: DNA甲基化; 2型糖尿病; 缺血性卒中

CUI Lingyun, QIU Xin, ZHOU Hongyu, LI Zixiao, WANG Yongjun. Progress of the Relationship between DNA Methylation and Type 2 Diabetes [J]. Chinese Journal of Stroke, 2022, 17(11): 1183-1188.

崔凌云, 仇鑫, 周宏宇, 李子孝, 王拥军. DNA甲基化与2型糖尿病的相关性研究进展[J]. 中国卒中杂志, 2022, 17(11): 1183-1188.

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