Research Advances on Mechanisms of Increased Stroke Risk by Circadian Rhythm Disruption

doi:10.3969/j.issn.1673-5765.2023.05.005

Abstract

Abstract: The causes of circadian rhythm disorders mainly including internal factors: internal circadian rhythm sleep-wake disorders, as well as external factors: social jet lag, shift work, artificial light during night, travel across time zones, stay up late, irregular diet, etc. Internal/external factors can lead to central and peripheral circadian clock disorder. Circadian clock genes regulate the expression of almost the entire genome. Circadian clock disorder leads to glucose-insulin metabolic disorder, hypertension, dyslipidemia, immune activation, obesity, premature aging, which are risk factors of stroke. The relationship between the circadian rhythm disturbance in addition to its caused above-mentioned risk factors and the risk of stroke is attracting increasing attention in recent years. This article reviews the research progress on the mechanism of circadian rhythm disturbance increasing the risk of stroke.

Key words: Stroke; Suprachiasmatic nucleus; Circadian rhythm disturbance

摘要： 昼夜节律紊乱的原因可分为内部因素和外部因素，内部因素指内在昼夜节律睡眠-觉醒调节机制障碍；外部因素包括社交时差、轮班工作、夜间人造光、跨时区旅行、熬夜、饮食不规律等。内部/外部因素可以导致中枢和外周的生物钟紊乱，生物钟基因调控几乎整个基因组的表达，生物钟紊乱可导致葡萄糖-胰岛素代谢紊乱、高血压、血脂异常、免疫激活、肥胖、早衰等，而这些因素也正为卒中的危险因素。近年来，昼夜节律紊乱及其导致的上述脑血管病危险因素与卒中发病风险的关系日益受到关注。本文就昼夜节律紊乱增加卒中风险机制的研究进展进行综述。

关键词: 卒中; 视交叉上核; 昼夜节律紊乱

JIA Hui, WANG Di, SUO Rui, WEI Xinya, ZHU Yulan.

Research Advances on Mechanisms of Increased Stroke Risk by Circadian Rhythm Disruption

[J]. Chinese Journal of Stroke, 2023, 18(05): 520-526.

贾慧, 王迪, 所芮, 卫馨雅, 朱雨岚. 昼夜节律紊乱增加卒中风险机制的研究进展[J]. 中国卒中杂志, 2023, 18(05): 520-526.

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