Abstract: Objective To study the relationship between the metabolic syndrome (MS) with its components and atherothrombotic cerebral infarction(ATCI).Methods 508 ATCI patients (308 men and 200 women) who fulfilled the diagnostic criteria of the China Guideline for Cerebrovascular Disease Prevention and Treatment were enrolled. 233 control subjects (102 men and 131 women) without the clinical signs of cerebral infarction were selectedby detailed case history and physical examination and CT or MRI. The prevalence and risk of MS was observed in ATCI group and control. MS was defined by the modified criteria in Chinese.Results The prevalence of MS in ATCI groups was respectively 39.0% in men and 46.0% in women. The prevalence of MS was significantly high in ATCI groups compared with control subjects (P <0.01). The components level of MS had significant difference between ATCI groups and control subjects (P <0.05). The MS was associated with respectively 5.60 and 2.75 fold higherrisk of ATCI in men and women(P <0.01).Conclusion There was a close relationship between MS and ATCI. The MS was an important risk factor of ATCI.

Key words: 【Key Words】 Metabolic syndrome; Atherosclerosis; Cerebral infarction; Risk factor

摘要： 目的 研究代谢综合征（metabolic syndrome，MS）及其各组分与动脉粥样硬化性血栓性脑梗死（atherothrombotic cerebral infarction，ATCI）的关系。方法 ATCI组508例，其中男性亚组308例，女性亚组200例；对照组233例，其中男性亚组102例，女性亚组131例，均为门诊体检者。观察MS在ATCI男、女性亚组和对照男、女性亚组的患病率、MS各组分水平以及MS对ATCI的危险度。MS诊断采用修订后的中国人MS诊断标准。结果 ATCI男性亚组和对照男性亚组MS的患病率分别为39.0%和9.8%，两组差异有统计学意义（P <0.01）。ATCI女性亚组和对照女性亚组MS的患病率分别为46.0%和19.1%，两组差异有统计学意义（P <0.01）。ATCI组MS各组分水平与同性别对照组间差异均有统计学意义（P均<0.05）。MS使ATCI男性亚组和女性亚组的发病率分别增加5.60和2.75倍（P <0.01）。结论 MS与ATCI关系密切，MS是ATCI的重要危险因素。

关键词: 代谢综合征; 动脉粥样硬化; 脑梗死; 危险因素