Abstract: Objective To study the changes of blood coagulation activity, anti-coagulation activity andhemorheology in patients with acute cerebral infarction.Methods Venous blood samples were collected from 40 patients with acute cerebral infarctionand 30 healthy individuals, to examine the levels of Fib, AT-III:α with blood coagulation analyzerand hemorheology indexes with automatic hemorheology instrument and to compare thedifferences between the two groups.Results Fibrinogen(Fib) of the acute cerebral infarction group(4.3±1.6g/L) are higher than thatof the control group(2.9±1.4g/L), which has significant difference(P <0.01). The whole bloodviscosity, plasma viscosity, hematocrit (HCT) and erythrocyte sedimentation rate (ESR) of theacute cerebral infarction group are higher than those of the control group,which has significantdifference (P <0.05), AT-III:α decreases obviously at acute stage of cerebral infarction, whichhas significant difference also(P <0.01).Conclusion After acute cerebral infarction, Fib and blood viscosity increase, blood coagulantactivity increases and anticoagulant activity decreases.

Key words: Cerebral infarction; Fibrinogen; Antithrombin III; Hemorheology

摘要： 目的 研究急性缺血性卒中患者凝血活性、抗凝活性和血液流变学的变化规律。方法 选择40例急性缺血性卒中患者和30例健康体检者，采集静脉血，用血凝仪检测血浆纤维蛋白原（Fibrinogen，Fib）、抗凝血酶Ⅲ活性（Antithrombin Ⅲ:α，AT-Ⅲ:α），用自动血流变测试仪检测血液流变学的指标。对比两组上述指标的差异。结果 缺血性卒中后急性期Fib（4.3±1.6g/L）高于对照组（2.9±1.4g/L），有统计学差异（P<0.01），全血和血浆黏度、红细胞压积、红细胞沉降率高于对照组，均有统计学差异（P<0.05），ＡＴ-Ⅲ:α在急性期明显低于对照组，有统计学差异（P<0.01）。结论 缺血性卒中急性期Fib升高，血液黏度增加，凝血活性增强及抗凝血活性降低。

关键词: 脑梗死; 纤维蛋白原; 抗凝血酶Ⅲ; 血液流变学