Abstract: Integrins are important adhesion molecules on cell surface. In the centralnervous system (CNS), they are involved in development and in the adult in areas as diverse assynaptogenesis and activation of microglia, they can also mediate leukocyte extravasation duringCNS inflammation. Recent studies have revealed that integrin alphaVbeta3 (αVβ3) is associatedwith the angiogenesis in many organs including the brain and the hemodynamic changes afterischemic stroke, especially the protection effect of the ischemic tissue by the selective antagonistsof integrin αVβ3 make it a therapeutic target of ischemic stroke and a new interest of these years.

Key words: Brain infarction; Integrin alphaVbeta3; Angiogenesis; Cerebral protection; Hemodynamics

摘要： 整合素是细胞表面重要的黏附分子，它在中枢神经系统内有多种重要的作用，如参与其发育、突触新生、炎症反应以及调节小胶质细胞的功能等，近年研究发现整合素αVβ3与包括脑在内的多个部位的血管新生以及脑缺血后血流动力学的改变等都有密切的关系，尤其是其特异性阻断剂对缺血脑组织的保护作用使得整合素αVβ3作为治疗缺血性卒中的新靶点而成为近年研究的热点。

关键词: 脑梗死; 整合素αVβ3; 血管新生; 脑保护; 血流动力学