Abstract: Objective To explore the change of some factors tissue-type plasminogen activator(t-PA) and plasminogen activator inhibitor-1(PAI-1) in the patients with acute cerebrovascular disease and to provide some theorical evidences for the clinical treatment.Methods The level of t-PA, PAI-1 antigen in the 78 patients with acute cerebral hemorrhage, cerebral infarction and transient ischemic attack(TIA) was determined by enzyme-linked immunosorbnent assay(ELISA) from October 2007 to September 2008. These data were compared with control group, which contains 22 patients.Results To the cerebral hemorrhage, the level of t-PA of experimental group was higher than those of the control group(P<0.001). The level of PAI-1 antigen was lower than those of the control group(P<0.001). The differences between the experimental group and the control group were significant. To the cerebral infarction, the level of t-PA and PAI-1 antigen of experimental group was higher than those of the control group(P<0.001). In TIA, the level of PAI-1 antigen in experimental group was higher than those in control group(P<0.001). The level of t-PA was lower(P=0.006). The differences between the experimental group and the control group were significant(P<0.001).Conclusion To the patients with acute cerebrovascular diseases, there is disturbance of blood coagulation, anticoagulation and fibrolysis.

Key words: Acute cerebrovascular disease; Cerebral hemorrhage; Cerebral infarction; Transient ischemic attack; Coagulation; Fibrolysis

摘要： 目的 探讨急性脑血管病患者血浆组织型纤溶酶原激活物（tissue-type plasminogen activator，t-PA）及纤溶酶原激活物抑制剂-1（plasminogen activator inhibitor-1，PAI-1）抗原含量的变化规律。方法 运用酶联免疫吸附法（enzyme-linked immunosorbent assay，ELISA）法测定2007年10月至2008年9月78例急性脑出血、脑梗死和短暂性脑缺血发作（transient ischemic attack，TIA）患者血浆t-PA及PAI-1抗原含量水平，并与同期22例健康对照组进行比较。结果 与对照组比较，脑出血组血浆t-PA水平明显升高、PAI-1水平降低（P均<0.001）；脑梗死组血浆t-PA及PAI-1水平均较对照组明显升高（P均<0.001）；TIA组血浆t-PA水平低于对照组（P=0.006），PAI-1水平升高（P<0.001）。结论 急性脑血管病患者存在纤溶活性的异常。

关键词: 急性脑血管病; 脑出血; 脑梗死; 短暂性脑缺血发作; 凝血; 纤溶