Abstract: Objective To observe the efficacy of Nimodipine on vascular cognitive impairment in a shortperiod treatment.Methods It was a prospective opened own control study. Sixty-four patients with cerebrovascular disease were recruited from outpatient of neurology department. On the basis of secondary prevention drugs, patients were given to oral Nimodipine 60-90 mg/d. The patients' cognitive functions have been assessed using the mini mental state examination(MMSE) and Montrealcognitive assessment(MoCA) before and after 12-24 weeks treatment.Results After treatment of Nimodipine, the performance record were significantly better than before, total scores of MMSE were 26.3±2.7 vs 25.6±2.9(P =0.039), MoCA were 20.5±4.6 vs 19.0±4.1(P =0.000), and the memory test of MoCA were significant better than before(1.8±1.7 vs 1.1±1.2, P =0.000).Conclusion Nimodipine may have some benefits for cognitive function in patients with cerebralvascular disease

Key words: Cerebral vascular disease; Cognitive; Nimodipine

摘要： 目的 该研究旨在观察尼莫地平片对血管性认知损害的短期疗效。方法 前瞻性开放性自身对照研究。64例神经内科门诊脑血管病患者，在常规二级预防药物的基础上，口服尼莫地平60～90 mg/d，12～24周。应用简明精神状态量表（mini mental state examination，MMSE）和北京版蒙特利尔认知评估量表（Montreal cognitive assessment，MoCA）作为认知评估工具，观察治疗前后患者认知功能的变化。结果 三个月治疗后认知成绩总分显著高于治疗前，分别为：MMSE（26.3±2.7）vs（25.6±2.9），P =0.039；MoCA（20.5±4.6）vs（19.0±4.1），P =0.000，差异有显著性；治疗后MoCA的记忆分测验成绩显著高于治疗前，分别为（1.8±1.7）vs（1.1±1.2），P =0.000，差异有显著性。结论 尼莫地平可有效地提高脑血管病患者的认知功能

关键词: 脑血管病; 认知功能; 尼莫地平