Autophagy after Ischemic Stroke

Abstract

Abstract:

【Abstract】 Autophagy is an important way to remove the aging protein and damaged organelles. As a subtype of cell death, autophagy plays an important role in pathological and physiological conditions. There indeed is an autophagic phenomenon after ischemic insult in brain. Discussing the autophagy activation pathways and how to evaluate it in quality and quantity will be helpful to figure out the role of autophay after ischemic stroke.

Key words: Autophagy; Ischemic stroke; Apoptosis; Necrosis

摘要：

【摘要】自噬是机体清除过量、老化蛋白质及受损细胞器的重要途径。作为细胞死亡的一种形式，自噬在病理、生理条件下均具有重要作用。缺血性卒中后存在明确的自噬现象。了解自噬激活途径及调控位点，对其进行定位、定性以及定量检测，有助于理解自噬在缺血性卒中发生、发展过程中的作用。

关键词: 自噬; 缺血性卒中; 凋亡; 坏死

SUN Jin-Mei, ZHANG Yong-Bo, LI Ji-Mei. Autophagy after Ischemic Stroke[J]. Chinese Journal of Stroke, 2013, 8(04): 311-315.

孙金梅，张拥波，李继梅. 自噬在缺血性卒中后的作用[J]. 中国卒中杂志, 2013, 8(04): 311-315.

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