Progress of Genetic Epidemiology of Ischemic Stroke

Abstract

Abstract:

【Abstract】 Stroke is one of the most serious diseases that threaten human health with heavy disease burden. Ischemic stroke is the most common type of stroke, which accounts for about eighty percent. Genetics and epidemiological study of twin and family has indicated that stroke has obvious genetic predisposition. Recently, candidate gene study and genome-wide association study on stroke has been developing rapidly. In this review, we discussed the progress of previous studies focused on the predisposing genes associated with ischemic stroke onset, e.g. lipid metabolism, inflamtation, renin-angiotensin-aldosterone system, homocysteine metabolism, nitric oxide synthase, as well as the genes associated with heart disease.

Key words: Ischemic stroke; Signal nucleotide polymorphism; Genetic epidemiology

摘要：

【摘要】卒中是严重危害人类健康的疾病之一，给社会和患者家庭带来了沉重的负担。其中缺血性卒中占80%，是卒中的主要类型。双生子、同胞胎、家系的遗传和流行病学研究证明卒中具有明显的遗传倾向。近年来基于候选基因研究和全基因组关联研究的卒中遗传流行病学发展迅猛，这些研究主要集中在与卒中发病相关的危险基因的研究，包括脂质代谢、炎症反应、肾素-血管紧张素-醛固酮系统、同型半胱氨酸代谢、一氧化氮合酶等基因，以及与心脏病发病相关的基因以及其他基因等多方面，本文将从这些方面对卒中的遗传流行病学研究进行综述。

关键词: 缺血性卒中; 单核苷酸多态性; 遗传流行病学

SONG Yan-Li, CAI Jin-Le, PAN Yue-Song, LIU Gai-Fen.. Progress of Genetic Epidemiology of Ischemic Stroke[J]. Chinese Journal of Stroke, 2014, 9(03): 246-251.

宋彦丽，蔡金乐，潘岳松，刘改芬. 缺血性卒中的遗传流行病学研究[J]. 中国卒中杂志, 2014, 9(03): 246-251.

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