Inflammatory Response and Ischemic Stroke

doi:10.3969/j.issn.1673-5765.2020.01.018

Abstract

Abstract:

Inflammatory response is one of the important pathophysiology reactions after ischemic stroke, the process of which involves the joint participation of immune and inflammatory cells, activated inflammatory factors from different pathways and sources. Early microglia and neutrophils are activated, and the aggregation and infiltration of lymphocytes can increase the damage to brain tissue. Studies have found that under specific stimuli, neutrophils can change from a pro-inflammatory phenotype to an anti-inflammatory phenotype, which can protect brain cells; some T cell subtypes of lymphocytes can inhibit the expression of pro-inflammatory factors and regulate lymphocytes activity, which plays a protective role in the brain. After ischemic stroke onset, in addition to the local inflammatory response in the brain, the inflammatory response and immunosuppression from the peripheral circulation also participate in the pathophysiological reactions. Immune regulation may become a target for the treatment of ischemic stroke in the future.

Key words: Ischemic stroke; Inflammatory cell; Inflammatory response

摘要：

炎症反应是缺血性卒中后病理生理的核心内容，其过程涉及免疫和炎症细胞，不同途径和来源的被激活的炎症因子共同参与。早期小胶质细胞、中性粒细胞被激活，随之淋巴细胞的聚集和浸润也增加了对脑细胞的损伤；但也有研究发现，在特定刺激下，中性粒细胞可以从促炎表型向抗炎表型转变，进而保护脑细胞；淋巴细胞中部分T细胞亚型可以抑制促炎因子的表达、调节淋巴细胞的活性，从而起到脑保护作用。另外，在缺血性卒中后，除脑内局部的炎症反应外，外周循环的炎性反应和免疫抑制也参与其病理机制。免疫调节有望成为未来缺血性卒中治疗的靶点。

关键词: 缺血性卒中; 炎症细胞; 炎症反应

QIU Xiao-Xue, LI Shi-Wen, Yu Lu, Wu Yi-Ping, Lin Jie. Inflammatory Response and Ischemic Stroke[J]. Chinese Journal of Stroke, 2020, 15(01): 108-114.

邱晓雪，李世文，于鹭，武一平，林杰. 炎症反应与缺血性卒中[J]. 中国卒中杂志, 2020, 15(01): 108-114.

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