Progress of Repetitive Transcranial Magnetic Stimulation in the Treatment of Post-stroke Cognitive Impairment

doi:10.3969/j.issn.1673-5765.2020.07.004

Abstract

Abstract:

Cognitive impairment is a common complication after stroke, which seriously affects the process of rehabilitation and quality of life of patients. Repetitive transcranial magnetic stimulation (rTMS), a new non-invasive electrophysiological technique, alters the action potential of nerve cells to affect metabolism and electrical activity in the brain, which has been gradually used to treat post-stroke cognitive impairment in recent years. At present, rTMS has achieved positive effect in the rehabilitation of executive function, memory, language ability and visuospatial ability after stroke, and it is safe to operate in the range of treatment parameters recommended in relevant guidelines. However, there is still lack of large sample, multicenter, high quality randomized controlled trials to further define its optimal stimulation parameters and effects. Research on rTMS in treatment of post-stroke cognitive impairment is still in the exploratory stage, and further mechanism studies are expected in the future, to provide more strong evidence for rTMS in treatment of post-stroke cognitive impairment.

Key words: Stroke; Cognitive impairment; Repetitive transcranial magnetic stimulation

摘要：

认知障碍是卒中后常见并发症，严重影响患者康复进程及生活质量。重复经颅磁刺激（repetitive transcranial magnetic stimulation，rTMS）作为一种新型的非侵入性神经电生理技术，通过改变神经细胞动作电位影响脑内代谢和神经电活动，近年来逐渐被用于卒中后认知障碍的治疗。目前 rTMS在卒中后执行功能、记忆功能、语言能力及视空间能力的康复应用中均取得了较为积极的疗效，且在指南推荐的治疗参数范围内操作基本是安全的，但仍缺乏大样本、多中心、高质量的随机对照试验进一步明确其最佳刺激参数与治疗效果。rTMS治疗卒中后认知障碍的研究仍处于探索阶段，未来有望进行更深入的机制研究，为rTMS治疗卒中后认知功能障碍提供更切实有力的依据。

关键词: 卒中; 认知障碍; 重复经颅磁刺激

YIN Ming-Yu, HU Xi-Quan. Progress of Repetitive Transcranial Magnetic Stimulation in the Treatment of Post-stroke Cognitive Impairment[J]. Chinese Journal of Stroke, 2020, 15(07): 713-719.

尹明宇，胡昔权. 重复经颅磁刺激治疗卒中后认知障碍的研究进展[J]. 中国卒中杂志, 2020, 15(07): 713-719.

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