Hot Spots and Trends in Stroke and Blood-Brain Barrier Research from 2001 to 2023: A Bibliometric-Based Study and Knowledge Graph Analysis

doi:10.3969/j.issn.1673-5765.2024.05.011

Abstract

Abstract: Objective A bibliometric analysis of the literature related to stroke and the blood-brain barrier was conducted to obtain a research map, explore hotspots and trends, and provide references for clinical treatment and research.
Methods The literature related to stroke and blood-brain barrier from 1 January 2001 to 28 February 2023 was explored in the Web of Science core database. Using bibliometrics, CiteSpace V6.1.R6 was used to analyze the distribution of years, countries/regions, research institutions/system, authors, publications, cited literature, keywords and research trends.
Results A total of 5028 papers were included after screening, with an overall upward trend in the number of published papers. The United States had the most research on this topic, followed by China’s mainland and Germany. Most of the top 10 research institutions/system were from the United States, France and China, with strong collaboration between countries/regions and research institutions/system. Among the authors, Chopp Michael from the United States ranked first with 49 papers. Among the research trends, ischemic stroke, miR-126 in non-coding RNA, blood-brain barrier dysfunction and drug delivery were the hot spots in the last three years.
Conclusions Blood-brain barrier and stroke are inextricably linked. The dysfunction and repair mechanism of blood-brain barrier during stroke, the circulation biomarkers released by blood-brain barrier and the use of blood-brain barrier opening time to increase drug absorption are worthy of further study.

Key words: Stroke; Blood-brain barrier; Bibliometrics

摘要： 目的对卒中和血脑屏障相关文献进行文献计量学分析得到研究图谱，探索热点和发展趋势，为临床治疗和研究提供参考。
方法在Web of Science核心数据库中检索2001年1月1日—2023年2月28日关于卒中和血脑屏障的文献，采用文献计量学方法，运用CiteSpace V6.1.R6对年份分布、国家/地区、研究机构/体系、作者、发行刊物、被引文献、关键词和研究趋势进行分析。
结果筛选后共纳入文献5028篇，发文量整体呈上升趋势，美国对此的研究最多，其次是中国大陆、德国等。发文量排名前10位的研究机构/体系大多来自美国、法国和中国，各国家/地区和研究机构/体系之间的合作很紧密。在研究作者中，来自美国的Chopp Michael发表文章49篇，位列第1位。在研究趋势中，缺血性卒中、非编码RNA中miR-126、血脑屏障功能障碍和药物递送是近3年的热点。
结论血脑屏障和卒中密不可分，卒中时血脑屏障的功能障碍和修复机制、血脑屏障所释放的循环生物标志物及利用血脑屏障开放时间增加药物吸收值得进一步研究。

关键词: 卒中; 血脑屏障; 文献计量学

CLC Number:

GU Zheng, JIANG Hailun, WU Mingfen, ZHAO Zhigang, SUN Aning. Hot Spots and Trends in Stroke and Blood-Brain Barrier Research from 2001 to 2023: A Bibliometric-Based Study and Knowledge Graph Analysis[J]. Chinese Journal of Stroke, 2024, 19(5): 552-562.

谷铮, 姜海伦, 武明芬, 赵志刚, 孙阿宁. 2001—2023年卒中和血脑屏障研究的热点及趋势：文献计量和知识图谱分析[J]. 中国卒中杂志, 2024, 19(5): 552-562.

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