Factors Influencing Frailty in Chinese Stroke Patients: A Meta-Analysis

doi:10.3969/j.issn.1673-5765.2025.02.011

Abstract

Abstract: Objective To systematically analyze the related factors of frailty in Chinese stroke patients, providing references for identifying the risk of frailty in stroke patients.
Methods Computer searches were conducted on cohort studies, case-control studies, and cross-sectional studies related to frailty in Chinese stroke patients from CNKI, Wanfang, VIP, Chinese Biomedical Literature Service System, Web of Science, Pubmed, Cochrane Library, and Embase. The search period was from the establishment of these databases until June 30, 2024. Two researchers independently conducted literature screening, quality evaluation, and data extraction based on inclusion and exclusion criteria. Stata 15.0 statistical software was used to conduct a meta-analysis on the possible factors influencing frailty.
Results A total of 16 studies were finally included, with a total sample size of 3857 cases. Meta-analysis showed that the influencing factors of frailty in stroke patients include aging (OR 1.07, 95%CI 1.02-1.11, P=0.002), age>75 years (OR 2.89, 95%CI 1.76-4.74, P<0.001), admission NIHSS score>14 points (OR 4.61, 95%CI 2.04-10.42, P<0.001), malnutrition (OR 3.14, 95%CI 1.04-9.50, P=0.043), depression (OR 4.15, 95%CI 1.95-8.85, P<0.001), diabetes mellitus (OR 3.27, 95%CI 1.76-6.08, P＜0.001), impaired activity of daily living (OR 2.37, 95%CI 1.22-4.61, P=0.011), and normal activity of daily living (OR 0.96, 95%CI 0.95-0.97, P＜0.001).
Conclusions There are many factors related to the frailty of stroke patients in China. Among them, normal activity of daily living is a protective factor for frailty, while aging, high admission NIHSS score, malnutrition, depression, diabetes mellitus, and impaired activity of daily living are risk factors for frailty.

Key words: Frailty; Stroke; China; Influencing factor; Meta-analysis

摘要： 目的系统分析中国卒中患者衰弱的相关因素，为识别卒中患者的衰弱风险提供参考。
方法计算机检索中国知网、万方、维普、中国生物医学文献服务系统、Web of Science、PubMed、Cochrane Library、Embase等数据库中有关中国卒中患者衰弱相关因素的队列研究、病例对照研究、横断面研究等观察性研究，检索时限为建库至2024年6月30日。由2名研究者按照纳入与排除标准独立进行文献筛选、质量评价和资料提取。采用Stata 15.0统计软件对衰弱的可能影响因素进行meta分析。
结果最终纳入16篇研究，总样本量为3857例。meta分析显示，卒中患者衰弱的相关因素包括增龄（OR 1.07，95%CI 1.02～1.11，P=0.002）、年龄＞75岁（OR 2.89，95%CI 1.76～4.74，P＜0.001）、入院NIHSS评分＞14分（OR 4.61，95%CI 2.04～10.42，P＜0.001）、营养不良（OR 3.14，95%CI 1.04～9.50，P＝0.043）、抑郁（OR 4.15，95%CI 1.95～8.85，P＜0.001）、糖尿病（OR 3.27，95%CI 1.76～6.08，P＜0.001）、日常生活能力受损（OR 2.37，95%CI 1.22～4.61，P=0.011）、日常生活能力正常（OR 0.96，95%CI 0.95～0.97，P＜0.001）。
结论中国卒中患者衰弱的相关因素较多，其中日常生活能力正常是衰弱的保护因素，而增龄、入院NIHSS评分高、营养不良、抑郁、糖尿病和日常生活能力受损是衰弱的危险因素。

关键词: 衰弱; 卒中; 中国; 影响因素; 系统分析

CLC Number:

YU Shenyan, MAO Xiaorong, XU Yehua, LI Youqing, ZENG Xia, LIANG Guangyao. Factors Influencing Frailty in Chinese Stroke Patients: A Meta-Analysis[J]. Chinese Journal of Stroke, 2025, 20(2): 208-217.

余深艳, 毛孝容, 许叶华, 李铀氢, 曾霞, 梁光耀. 中国卒中患者衰弱相关因素meta分析[J]. 中国卒中杂志, 2025, 20(2): 208-217.

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