Effects of Exercise on Brain Neurogenesis and Angiogenesis after Ischemic Stroke

Abstract

Abstract:

Pathophysiologic responses in brain after stroke are highly complex. Thus far, a singular focus on saving neurons alone has not revealed any clinically effective neuroprotection. To address this limitation, the concept of a neurovascular unit was developed. The vascular niche hypothesis highlights the complex interactions of neuro- and angiogenesis for regenerative and repair mechanisms in the human brain. In this review, we briefly describe the protective and therapeutic effects of exercise on stroke. The protective mechanisms induced by exercise include increased perfusion as well as mechanisms of neurogenesis, collateral recruitment and angiogenesis. The purpose of this review is to evaluate the evidence that angiogenesis is a target for recovery after an ischemic stroke.

Key words: Angiogenesis; Neurogenesis; Exercise; Ischemic stroke; Neurovascular uni

摘要：

缺血性卒中后的病理生理反应很复杂，单纯注重挽救神经元在临床研究中并不能有效达到神经保护作用。神经血管单位中的“血管龛”假说强调神经再生和血管再生之间复杂的相互作用，从而有效修复脑缺血损伤。本综述中主要简述了运动锻炼对缺血性卒中的保护和治疗作用，运动疗法的保护机制包括增加脑灌注、促进神经再生、侧支循环、血管再生等。本综述旨在认识血管再生的重要性，可望其成为缺血性卒中治疗的新途径。

关键词: 血管再生; 神经再生; 运动; 缺血性卒中; 神经血管单位

ZHAI Zhi-Yong, FENG Juan. . Effects of Exercise on Brain Neurogenesis and Angiogenesis after Ischemic Stroke [J]. Chinese Journal of Stroke, 2015, 10(01): 88-91.

翟志永，冯娟. 脑缺血后运动疗法的神经再生与血管再生机制[J]. 中国卒中杂志, 2015, 10(01): 88-91.

References

参考文献

1 于频. 系统解剖学[M]. 4版. 北京:人民卫生出版社, 1999:264.

2 Ginsberg MD. Neuroprotection for ischemic stroke: past, present and future[J]. Neuropharmacology, 2008, 55:363-389.

3 陈萍, 陈立云, 王拥军. 缺血性卒中的神经血管单元保护研究进展[J]. 中国卒中杂志, 2007, 2:1003-1008.

4 Navarro-Sobrino M, Rosell A, Hernandez-Guillamon M, et al. A large screening of angiogenesis biomarkers and their association with neurological outcome after ischemic stroke[J]. Atherosclerosis, 2011, 216:205-211.

5 Hagg T. From neurotransmitters to neurotrophic factors to neurogenesis[J]. Neuroscientist, 2009, 15:20-27.

6 Arvidsson A, Collin T, Kirik D, et al. Neuronal replacement from endogenous precursors in the adult brain after stroke[J]. Nat Med, 2002, 8:963-970.

7 Thored P, Arvidsson A, Cacci E, et al. Persistent production of neurons from adult brain stem cells during recovery after stroke[J]. Stem Cells, 2006, 24:739-747.

8 Greenberg DA, Jin K. From angiogenesis to neuropathology[J]. Nature, 2005, 438:954-959.

9 Ding J, Cheng Y, Gao S, et al. Effects of nerve growth factor and noggin-modified bone marrow stromal cells on stroke in rats[J]. J Neurosci Res, 2011, 89:222-230.

10 Jiang WL, Zhang SP, Zhu HB, et al. Effect of 8-o-acetyl shanzhiside methylester increases angiogenesis and improves functional recovery after stroke[J]. Basic Clin Pharmacol Toxicol, 2011, 108:21-27.

11 Manoonkitiwongsa PS, Jackson-Friedman C, McMillan PJ, et al. Angiogenesis after stroke is correlated with increased numbers of macrophages:The clean-up hypothesis[J]. J Cereb Blood Flow Metab, 2001, 21:1223-1231.

12 Petraglia AL, Marky AH, Walker C, et al. Activated protein C is neuroprotective and mediates new blood vessel formation and neurogenesis after controlled cortical impact[J]. Neurosurgery, 2010, 66:165-171.

13 Stroke Progress Review Group of National Institute of Neurological Disorders and Stroke. Report of the Stroke Progress Review Group of 2002[EB/OL]. http://www.ninds.nih.gov/about_ninds/groups.[2002-04-14](2014-03-20).

14 Palmer TD, Willhoite AR, Gage FH. Vascular niche for adult hippocampal neurogenesis[J]. J Comp Neurol, 2000, 425:479-494.

15 Beck H, Plate KH. Angiogenesis after cerebral ischemia[J]. Acta Neuropathol, 2009, 117:481-496.

16 Li Y, Chopp M. Marrow stromal cell transplantation in stroke and traumatic brain injury[J]. Neurosci Lett, 2009, 456:120-123.

17 Taguchi A, Soma T, Tanaka H, et al. Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model[J]. J Clin Invest, 2004, 114:330-338.

18 中村隆一. 脑卒中康复[M]. 朱裕祥, 译. 上海:华东师范大学出版社, 1994:89.

19 Nudo RJ, Wise BM, Sifuentes F, et al. Neursubsratees for the effects of rehabilitative training on motor recover following ischemic infarct[J]. Science, 1996, 272:1791-1794.

20 Traversa R, Cicinelli P, Bassi A, et al. Mapping of motor cortical reorganization after stroke:a brain stimulation study with focal magnetic pulses[J]. Stroke, 1997, 28:110-117.

21 Kim YH, Park JW, Ko MH, et al. Plastic changes of motor network after constraint-induced movement therapy[J]. Yonsei Med J, 2004, 45:241-246.

22 Levy CE, Nichols DS, Schmalbrok PM, et al. Functional MRI evidence of cortical reorganizition in upper-limb stroke hemiplegia treated with constraint-induced movement therapy[J]. Am J Phys Med Rehabit, 2001, 80:4-12.

23 赵传胜, 戚其学, 赵珊珊, 等. 脑缺血后强制性运动疗法对内源性神经干细胞及基质细胞衍生因子-1水平的影响[J]. 中国血液流变学杂志, 2007, 17:521-524.

24 Chalasani SH, Sabelko KA, Sunshine MJ, et al. A chemokine, SDF-1, reduces the effectiveness of multiple axonal repellents and is required for normal axon pathfinding[J]. J Neurosci, 2003, 23:1360-1371.

25 Schwab ME. Nogo and axon regeneration[J]. Curr Opin Neurobiol, 2004, 14:118-124.

26 He Z, Koprivica V. The nogo signaling pathway for regeneration block[J]. Annu Rev Neurosci, 2004, 27:341-368.

27 Fournier AE, Takizawa BT, Strittmatter SM. Rho kinase inhibition enhances axonal regeneration in the injured CNS[J]. J Neurosci, 2003, 23:1416- 1423.

28 Zhao S, Zhao M, Xiao T, et al. Constraint-induced movement therapy overcomes the intrinsic axonal growth-inhibitory signals in stroke rats[J]. Stroke, 2013, 44:1698-1705.

29 翟志永, 聂莹雪, 赵传胜, 等. 强制性运动疗法对大鼠脑缺血再灌注后神经修复及Rho激酶表达的影响[J]. 中国医科大学学报, 2008, 37:295-298.

30 Rolland Y, van Kan GA, Vellas B. Healthy brain aging:role of exercise and physical activity[J]. Clin Geriatr Med, 2010, 26:75-87.

31 Leung FP, Yung LM, Laher I, et al. Exercise, vascular wall and cardiovascular diseases:an update. Part 1[J]. Sports Med, 2008, 38:1009-1024.

32 Zhang F, Wu Y, Jia J. Exercise preconditioning and brain ischemic tolerance[J]. Neuroscience, 2011, 177:170-176.

33 Vander Borght K, Kóbor-Nyakas DE, Klauke K, et al. Physical exercise leads to rapid adaptations in hippocampal vasculature:temporal dynamics and relationship to cell proliferation and neurogenesis[J]. Hippocampus, 2009, 19:928-936.

34 Pereira AC, Huddleston DE, Brickman AM, et al. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus[J]. Proc Natl Acad Sci USA, 2007, 104:5638-5643.

35 Seevinck PR, Deddens LH, Dijkhuizen RM. Magnetic resonance imaging of brain angiogenesis after stroke[J]. Angiogenesis, 2010, 13:101-111.

36 Endres M, Gertz K, Lindauer U, et al. Mechanisms of stroke protection by physical activity[J]. Ann Neurol, 2003, 54:582-590.

37 Gertz K, Priller J, Kronenberg G, et al. Physical activity improves long-term stroke outcome via endothelial nitric oxide synthase-dependent augmentation of neovascularization and cerebral blood flow[J]. Circ Res, 2006, 99:1132-1140.

38 Ding YH, Young CN, Luan X, et al. Exercise preconditioning ameliorates inflammatory injury in ischemic rats during reperfusion[J]. Acta Neuropathol, 2005, 109:237-246.

39 Rehman J, Li J, Parvathaneni L, et al. Exercise acutely increases circulating endothelial progenitor cells and monocyte/macrophage-derived angiogenic cells[J]. J Am Coll Cardiol, 2004, 43:2314-2318.

40 Laufs U, Werner N, Link A, et al. Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis[J]. Circulation, 2004, 109:220-226.

41 Sandri M, Adams V, Gielen S, et al. Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes:results of 3 randomized studies[J]. Circulation, 2005, 111:3391-3399.

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