1 中华医学会神经病学分会，中华医学会神经病学分

会脑血管病学组. 中国急性缺血性脑卒中诊治指南

2014[J]. 中华神经科杂志，2015，4：246-257.

2 陶录岭. 基于调节SDF-1α/CXCR4轴的脑脉通对脑缺

血/再灌注老龄大鼠脑微血管生成机制的研究[D]. 河

南中医学院，2014：1-95.

3 冉黎婧，史明霞，洪敏. 间充质干细胞归巢机会研究进

展[J]. 医学研究生学报，2014，27：423-426.

4 Kim H. Will the stromal-derived factor-1α (CXCL12)/

CXCR4 pathway become a major concer n for

advanced colorectal cancer?[J]. J Korean Soc

Coloprotol，2012，28：3-4.

5 达阳，孟秋宏，刘宏全，等. 干细胞救治缺血性肾损伤：

基质细胞衍生因子-1-CXCR4/CXCR7轴功效特征[J].

中国组织工程研究，2014，18：2250-2256.

6 Xing Y，Gu Y，Gomes RR，et al. P2Y(2) receptors and

GRK2 are involved in oscillatory fluid flow induced

ERK1/2 responses in chomdrocytes[J]. J Orthop Res，

2011，29：823-833.

7 Tu X，Yang W，Liang R，et al. Effect of baicalin on

matrix metalloproteinase-9 expression and bloodbrain

barrier permeability following focal cerebral ischemia in rats[J]. Neurochem Res，2011，36：2022-

2028.

8 Zhou X，Porter AL，Robinson DK，et al. Nanoenabled

drug delivery：A research profile[J]. Nanomedicine，

2014，10：889-896.

9 张文文，林明，许昌声. 缺氧诱导因子-1α小干扰RNA

对骨髓间充质干细胞缺氧诱导因子-1α、基质细胞衍

生因子-1α和血管内皮生长因子基因表达的影响[J]. 中

国组织工程研究与临床康复，2010，14：6759-6763.

10 李士勇，邓宇斌. SDF-1/CXCR4轴在缺氧缺血性脑损

伤中的研究进展[J]. 生命科学，2008，20：463-466.

11 Hei n isch，S，Ki rby LG. SDF-1alpha/CXCL12

enhances GABA and glutamate synaptic activity at

serotonin neurons in the rat dorsal raphe nucleus[J].

Neuropharmacology，2010，58：501-514.

12 方丹，殷明，游捷. CXCL12(SDF-1)/CXCR4轴调控肺

癌及中医药干预研究进展[J]. 上海中医药大学学报，

2013，27：93-98.

13 Domanska UM，Kruizinga RC，Nagengast WB，et

al. A review on CXCR4/CXCL12 axis in oncology：no

place to hide[J]. Eur J Cancer，2013，49：219-230.

14 林轲羽，宿华威. 趋化因子受体在结直肠癌肝转移

研究中的新进展[J]. 世界华人消化杂志，2013，21：

2403-2411.

15 Si e r r o F，Biben C，Ma r t i ne z -Muf ioz L，e t

al. Disrupted cardiae development but normal

hematopoiesis in mice def icient in the second

CXCL12/SDF-1 receptor，CXCR7[J]. Proc Natl Acad

Sci USA，2007，104：14759-14764.

16 Levoye A，Balabanian K，Balwnx F，et al. CXCR7

heterodimerizes with CXCR4 and regulates CXCL12-

mediated G protein signaling[J]. Blood，2009，113：

6085-6093.

17 Callagher KA，Liu IJ，Xiao M，et al. Diabetic

impairments in NO-mediated endothelial progenitor

cell mobilization and homing are reversed by

hyperoxia and SDF-1 alpha[J]. J Clin Incest，2007，117：

1249-1259.

18 申明琪，初桂兰. CXCR4/SDF-1轴在BMSCs向新生小

鼠缺血缺氧脑组织定向迁移的潜在机制研究[J]. 中国

医药指南，2010，8：54-56.

19 Kayali AG，Lopez AD，Hao E，et al. The SDF-

1α/CXCR4 axis is required for proliferation and

maturation of human fetal pancreatic endocrine

progenitor cells[J]. PloS One，2012，7：e38721.

20 余刚，夏红利，李敏才. CXCR4+骨髓间充质干细胞迁

移与氧化型低密度脂蛋白致内皮细胞损伤[J]. 细胞与

分子免疫学杂志，2013，29：805-808.

21 Schiradi M，Raucci A，Munoz LM，et al. HMGB1

promates recruitment of inf lammatory cells to

damaged tissues by forming a complex with CXCL12 and signaling via CXCR4[J]. J Exp Med，2012，209：

551-563.

22 Dai X，Mao Z，Huang J，et al. The CXCL12/CXCR4

autorine loop increases the metastatic potential of

non-small cell lung cancer in vitro[J]. Oncol Lett，

2013，5：227-282.

23 Yang，S，Edman，LC，Sanchez-Alcaniz，JA，et al.

CXCL12/CXCR4 signaling controls the migration

and process orientation of A9-A10 dopaminergic

neurons[J]. Development，2013，140：4554-4564.

24 Shen L，Gao Y，Qian J，et al. The role of SDF-1α/Rac

pathway in the regulation of endothelial progenitor

cell polarity；homing and expression of Rac1，Rac2

during endothelial repair[J]. Mol Cell Biochem，2012，

365：1-7.

25 Kokovay E，Goderie S，Wang Y，et al. Adult SVZ

lineage cells home to and leave the vascular niche via

differential responses to SDF1/CXCR4 signaling[J].

Cell Stem Cell，2010，7：163-173.

26 Bakondi B，Shimada IS，Peterson BM，et al. SDF-

1α secreted by human CD133-derived multipotent

stromal cells promotes neural progenitor cell survival

through CXCR7[J]. Stem Cells Dev，2011，20：1021-

1029.

27 牟临杰，丁鹏，等. 基质细胞衍生因子1趋化神经干细

胞迁移的体外效应[J]. 中国组织工程研究与临床康

复，2011，15：5058-5062.

28 Li S，Wei M，Zhou Z，et a l. S DF-1α i nduce s

angiogenesis after traumatic brain injury[J]. Brain Res，

2012，1444：76-86.

29 庞宏刚，宋锦宁，李丹东，等. SDF-1α/CXCR4通路在

大鼠弥漫性轴索损害中的作用[J]. 西安交通大学学报，

2015，36：40-44.

30 Pe t t y JM，Suebl inveng V，Lenox CC，e t a l .

Pulmonary stromal-derived factor-1 expression and

effect on neutrophil recruitment during acute lung

injury[J]. J Immunol，2007，178：8148-8157.

31 Rosell A，Cuadrado E，Ortega-azner A，et al. MMP-

9-positive neurophil infiltration is associated to

blood-brain barrier breakdown and basal lamina

type IV collagen degradation during hemorrhagic

transformation ater human ischemic stroke[J]. Stroke，

2008，39：1121-1126.

32 Qiu J，Xu J，Zheng Y，et al. High-mobility group box1

promotes metalloproteinase-9 upregulation through

Toll-like receptor 4 after cerebral ischemia[J]. Stroke，

2010，41：2077-2082.

33 Venereau E，Schiraldi M，Uguccioni M，et al. HMGB1

and leukocyte migration during trauma and sterile

inflammation[J]. Mol Immunol，2013，55：76-82.

34 Jaerve，A，Müller，HW. Chemokines in CNS injury and repair[J]. Cell Tissue Res，2012，349：229-248.

35 Huang C，Gu H，Zhang W，et al. SDF-1/CXCR4

mediates acute protection of cardiac function through

myocardial STAT3 signaling following global

ischemia/reperfusion injury[J]. Am J Physiol Heart

Circ Physiol，2011，301：H1496-1505. 36 Zhao Y，Tan Y，Xi S，et al. A novel mechanism by

which SDF-1β protects cardiac cells from plamitateinduced

endoplasmic reticulum stress and apoptosis

via CXCR7 and AMOK/p38 MAPK-mediated

interleukin-6 generation[J]. Diabetes，2013，62:2545-

2558.