Advances in Intravenous Thrombolysis for Mild Stroke Patients

doi:10.3969/j.issn.1673-5765.2021.10.017

Abstract

Abstract: Whether mild stroke patients should receive thrombolytic therapy remains an unresolved problem. The definition and standard for mild stroke are not unified till now. Mild stroke accounts for a large proportion in stroke and has an increasing trend at home and abroad. It increased the risk of disability and stroke recurrence. Patients with mild stroke often fail to receive intravenous thrombolysis even if they arrive at the hospital within the 4.5-hour time window, and 29% of these patients without thrombolysis have a poor outcome. The safety and efficacy of thrombolytic therapy in patients with mild stroke are controversial. The time window, disability or not, NIHSS score, etiological type and other factors all can affect the prognosis. More studies are needed to evaluate the significance of thrombolytic therapy in patients with mild stroke.

Key words: Mild stroke; Thrombolytic therapy; Alteplase; Prognosis; Predictor

摘要： 轻型卒中的定义及标准目前尚未统一，其是否需要溶栓是卒中领域尚未解决的问题之一。轻型卒中在卒中患者中的比例较大且有上升趋势，并且增加致残和复发的风险。轻型卒中患者即便在 4.5 h内到达医院也常因症状较轻而未能接受溶栓治疗，而这些未溶栓患者中有29%预后不良。轻型卒中患者溶栓治疗的有效性及安全性均存在很大争议，而溶栓治疗的时间窗、卒中是否致残、NIHSS 评分、病因学分型等因素均可影响其预后，需要更多的研究来评估溶栓治疗对轻型卒中患者的意义。

关键词: 轻型卒中; 溶栓治疗; 阿替普酶; 预后; 影响因素

YAN Ran, XIONG Yun-Yun, LI Zi-Xiao. Advances in Intravenous Thrombolysis for Mild Stroke Patients[J]. Chinese Journal of Stroke, 2021, 16(10): 1075-1081.

闫然, 熊云云, 李子孝. 轻型卒中患者的溶栓治疗进展[J]. 中国卒中杂志, 2021, 16(10): 1075-1081.

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