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    20 February 2013, Volume 8 Issue 02
    Success Depends on Details
    WANG Yong-Jun
    2013, 8(02):  81-82. 
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    Stroke Imaging and Prospects for the Clinical Application of Computed Tomography Spectral Imaging
    XUE Jing, GAO Pei-Yi
    2013, 8(02):  83-86. 
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    Application of Spectral Computed Tomography 70 keV Monochromatic Image in the Posterior
    Cranial Fossa Imaging
    GU Wei-Bin*, GAO Pei-Yi, WU Chun-Xue, XUE Jing, MA Guo-Feng, GAO Jing-Sheng.
    2013, 8(02):  87-92. 
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    Objective To discuss the value of improving the quality of the image and the removal of hardening artifact for the usage of GE Discovery computed tomography(CT)750 HD 70 keV monochromatic image in the posterior cranial fossa imaging. Methods ①From June 2011 to October 2012, 87 patients were taken spectrum scan mode head CT scan in our hospital, 400 patients were taken conventional mixed energy head CT scan using GE Discovery CT750 HD, their image informations were used to create database respectively. ②From each database, 20 cases were extracted using random number method at random respectively. CT value and its standard deviation(SD) of 20 mm2 region of interest(ROI) were measured for different position of brain tissue inside posterior cranial fossa in the cases selected, including:midpoint of the bilateral internal auditory meatus, pons center and cerebellar white matter in the level with maximum 4th ventricle. Image quality was measured by the noise level(CT value standard deviation SD), and statistical analysis between the 2 groups was taken. In addition, from each database, 30 cases were extracted using random number method at random respectively. Then for the cases selected, score for the posterior fossa artifact was taken and a statistical analysis was made. Results All cases of spectrum scan mode 70 keV monochromatic image in our study can meet the diagnosis need of posterior cranial fossa. Median noise level of bilateral internal auditory meatus midpoint, pons center and cerebellar white matter in the level with maximum 4th ventricle are(unit:HU):70 keV monochromatic image group3.96(3.60, 4.24)、3.66(3.40, 3.92)、3.37(3.06, 3.65), mixed energy head CT group 5.52(5.16, 5.80)、4.52(4.15, 5.36)、4.26(3.95, 4.74), respectively. Compared to mixed energy head CT, noise index of different brain tissue position inside the posterior fossa is decreased significantly, there are significant statistical differences, all P<0.001. As to posterior cranial fossa artifact, median score of 70 keV monochromatic image(4, 3-4) is higher than the mixed energy CT image(3, 2-3), and there are significant statistical differences, P<0.001. Conclusions Spectrum scan mode 70 keV monochromatic image can meet the diagnosis need of posterior cranial fossa after initial studies. Compared with conventional mixed energy CT image, 70 keV monochromatic image can significantly reduce image noise of the posterior fossa brain parenchyma, improve image quality, and inhibit the artifact of posterior cranial fossa.

    Preliminary Application Study of Spectral Computed Tomography Volume Shuttle Scanning Technique in Moyamoya Disease
    ZHANG Ya-Nan*, GAO Pei-Yi, ZHANG Dong, GU Wei-Bin, MA Shu-Jie, XUE Jing.
    2013, 8(02):  92-99. 
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    Objective To investigate the value of spectral computed tomography(CT) volume shuttle scanning technique in assessment of vascular status and perfusion in patients with moyamoya disease. Methods Spiral CT volume shuttle scanning was performed in 4 preoperative cases and 11 postoperative cases with moyamoya disease, to obtain four dimensional computed tomography angiography(CTA) and whole brain CT perfusion images. The evaluation standards of noncontrast CT classification, internal carotid artery stage, collateral circulation classification, rich puff-like network stage, abnormal CT perfusion stage and Alberta Stroke Program Early CT Score were applied to analyze cerebral parenchyma and vascular lesions of moyamoya disease in left and right cerebral hemispheres. Results In 4 preoperative patients(8 hemispheres) with moyamoya disease, 5(62.5%) of 8 hemispheres were in stage Ⅲ of internal carotid artery stage. In this group, the collateral circulation(46.1%) mainly originated from skull base vascular network. In addition, 8 hemispheres(100%) appeared abnormal on computed tomography perfusion(CTP), 7 of which(87.5%) were in pre-infarction stage II, and had Alberta Stroke Program Early CT Score more than 10 points at the same time. In 11 cases(22 hemispheres) who underwent superficial temporal artery to middle cerebral artery bypass, 6 were performed on the left, 4 were completed on the right and 1 were double,whereas the bypass patency rate was 100%. Moreover, the infarction stage of 19 hemispheres(86.4%) were abnormal, in which 40.1%(9/22) were Ⅱ stage and 36.4%(8/22) were Ⅲ stage, respectively. Conclusion Four dimensional CT angiography and whole brain CT perfusion are obtained by spectral CT volume shuttle scanning technology. The images have great values for the assessment of internal carotid artery stage, collateral circulation, graft patency and cerebral hemodynamics changes postoperatively.

    Pathological Changes and Expression of Endothelin-1 in Vascular Wall of Cerebral Arteriovenous Malformations
    NIU Hong-Chuan*, WANG Rong, WANG Xue-Jiang, XUE Xiao-Wei, YANG Ming, DUAN Ran.
    2013, 8(02):  100-105. 
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    Objective To observe the pathological features of brain arteriovenous malformations(AVMs) and semiquantitatively measure the levels of endothelin-1(ET-1) in the blood vessels of AVMs in order to investigate the relationship between ET-1 and the rupture of AVMs. Methods Thirty-one patients diagnosed as AVMs were divided into ruptured group(n=15) and unruptured group(n=16). Our study had included the control group(the normal blood vessel excised from the other craniocerebral operation). The tissues of the blood vessel cut from the AVMs and the normal blood vessel were stained with Masson trichrome(collagen fibers) to evaluate the vessel-wall structure and endothelial integrity. Immunohistochemical staining was semiquantitatively performed to detect the content and distribution of ET-1 in the vessel wall and the differences among those three groups had been compared. Results The Masson trichrome staining demonstrated that the endothelial cells were damaged, smooth muscle cells were degenerated, and collagen fibers were proliferated in the media in the unruptured group. While in the ruptured group, the endothelium of blood vessel was severely damaged, the smooth muscle was obviously reduced, and almost was replaced by the collagen fibers. Mean grayscale intensity of ET-1 in the control group, non-ruptured group and ruptured group was 0.167±0.004, 0.196±0.007 and 0.231±0.012, respectively. The semi-quantitative study on vascular endothelial related factors found that ET-1 in ruptured group was significantly higher than that in unruptured group(P=0.019) and control group(P<0.001 ), and ET-1 in unruptured group was higher than that in control group(P=0.001 ). Conclusion The vessel walls of AVMs are damaged. The ruptured AVMs are severely damaged. ET-1 is highly expressed in the damaged wall of the AVM.

    Changes of High Sensitivity C-reactive Protein Level in the First Acute Cerebral Infarction Patients with Diffierent Etiology and Pathophysiology
    SHI Zhe*, WANG Yong-Jun.
    2013, 8(02):  106-110. 
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    Objective To investigate the regularity and clinical significance of high serum sensitivity C-reactive protein(hs-CRP) level in the first early acute cerebral infarction(ACI) patients with the different etiology and pathophysiology. Methods Four hundred and twenty-three patients were divided in accordance with the etiology and pathophysiology of Chinese Ischemic Stroke Subclassification(CISS). Serum hs-CRP levels within 7 days were detected and analysed by immune turbidimetry. Results In the different causes, cardiogenic stroke group has the highest hs-CRP level([8.09±4.47]mg/L), followed by the order of large artery atherosclerosis group([5.89±4.02]mg/L, other etiology group[5.21±4.64]mg/L), penetrating artery disease group([3.67±3.47]mg/L) and undetermined etiology group([2.83±4.40]mg/L), hs-CRP level of each group was significant different(F=7.905; P=0.015); The pathophysiology of thrombosis is different, hs-CRP level is not the same, order as follows:artery-to-artery embolism group([7.88±3.35]mg/L), multiple mechanisms group([5.88±3.50]mg/L), hypoperfusion/emboli clearance group([5.15±4.36]mg/L, penetrating artery group[4.48±3.88]mg/L), hs-CRP level of each group was significant different(F=15.821; P=0.013). Conclusion Hs-CRP levels were significant different in the first early acute cerebral infarction patients with the different etiology and pathophysiology.

    Concept and Principle of Spectral Computed Tomography
    XUE Yun-Jing, DUAN Qing.
    2013, 8(02):  112-115. 
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    The most prominent advantages of gemstone spectral computed tomography(CT) over conventional CT are its set of quantitative analysis and multi-parameter images, such as monochromatic images, spectral curve, material decomposition images and effective atomic number. Spectral CT provides not only an original tool for early diagnosis of diseases, quantitive evaluation and accurate diagnosis but also a novel platform for clinical and research. It is important for radiologists and clinicians to understand and be familiar with the concept and principle of spectral CT

    Clinical Application of Spectral Computed Tomography in Neuroradiology
    XUE Yun-Jing, DUAN Qing
    2013, 8(02):  116-119. 
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    Spectral computed tomography(CT), as advanced medical imaging equipment, offers the possibility to exploit spectral information including monochromatic images, spectral curve, material decomposition images and effective atomic number for diagnostic purpose. This review is to summarize the preliminary application and research of spectral CT in neuroradiology and to explore the value in clinical applications.

    One Case Report of Spectral Three-Dimension Computed Tomography Angiography
    Distinguished Intracranial Aneurysm from Negative findings on Digital Subraction Angiography
    GU Wei-Bin, XUE Jing
    2013, 8(02):  120-123. 
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    Evaluation and Treatment of Hypertriglyceridemia: an Endocrine Society Clinical Practice
    Guideline (Except Part 2)
    WU Jia, SHEN Dong-Chao, SHI Yu-Zhi, et al.
    2013, 8(02):  124-132. 
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    Research Advance on Computed Tomography Angiography in Central Nervous System Diseases
    ZHOU Yang*, GAO Pei-Yi, XUE Jing.
    2013, 8(02):  133-137. 
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    With the development of multi-slice computer tomography scan and recombinant techniques, computed tomography angiography(CTA) is widely used in central nervous system due to its convenient operation and minimal invasion. It contributes to the diagnosis of acute cerebral vascular diseases, aneurysm, arteriovenous malformations, moyamoya disease, tumors and spinal vascular disease, and provides evidence to the growth of massive hematoma. This paper reviews the imaging advantage, imaging technology and clinical research focus of CTA in the diseases.

    Leukoaraiosis and Cognitive Impairment
    SHI Qing-Li*, HAN Li-Kun, HUANG En-Yu, YUAN Chun, WANG Chun-Xue, ZHANG Yu-Mei.
    2013, 8(02):  138-141. 
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    Leukoaraiosis(LA) is one of the reasons of the subcortical ischemia, the relationship between LA and cognitive impairment remains controversial at home and abroad, such as, whether LA can cause cognitive impairment or not, which type of cognitive impairment can it cause, what's the relationship between the severity and the location of LA and cognitive impairment, and so on. This paper reviews the relationship between LA and cognitive impairment.

    Research Advance on Imaging Findings of Post-stroke Depression
    SU Lu*, XUE Jing, ZHANG Ning, WANG Chun-Xue.
    2013, 8(02):  142-146. 
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    Post-stroke depression(PSD) is a common complication of cerebrovascular disease, which may impede neurological rehabilitation of patients with PSD, even kill more patients suffering from stroke. Reports on the incidence of PSD vary from each other greatly; it is concentrated between 20% and 50%. Although regular imaging plays a significant role on the foundation and supports the hypothesis of limbic-cortical-striatal-pallidal-thalamic(LCSPT) circuit, it still cannot serves good to early identify of PSD compared with functional magnetic resonance imaging(MRI). Hence, functional MRI would lay the foundation and promote early identification and prevention of PSD on the basis of nowadays survey on depression.

    Neurogenesis, Stroke and Brain Aging
    ZHANG Hong-Xia*, SHAO Bei, WANG Liu-Qing, LIN Zhen-Zhen, XIAO Li, JIANG Hui-Gang, CHENG Yi-Fan, SU Qiao-Er, ZHEN Wei-Ming,ZHUGE Qi-Chuan, JIN Kun-Lin.
    2013, 8(02):  147-152. 
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    Brain aging, a common induced factor of neurodegenerative diseases, is associated with a striking increase in the incidence of stroke, which is a common disease of the nervous system and a major cause of disability and death among those aged 70 years and older. It is well documented that there are more serious brain ischemic changes, larger infarction area and more significant nerve dysfunction in elderly. Although many studies have confirmed decreased neurogenesis in aging brain, increased neurogenesis after stroke holds great promise for brain repair. This review seeks to integrate briefly what is known about neurogenesis and ischemic stroke after brain aging.

    Micro-Ribonucleic Acid and Ischemic Stroke
    LI Qian-Yun*, ZENG Li-Li, WANG Yong-Ting, YANG Guo-Yuan.
    2013, 8(02):  153-158. 
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    As gene-coded non-coding ribonucleic acids with the length of about 22 nucleotides, micro-ribonucleic acid(miRNAs) widely involved in the regulation of mRNA translation and proteins synthesis. This article mainly reviews researches focusing on the function of miRNAs in stroke. miRNAs play critical roles in normal brain development and function and their expression changes when cerebral ischemia occurs. These changes have direct relationship with pathophysiologic process downstream and ischemic tolerance. Studies of miRNAs function will help in developing potential stroke therapies through the modulation of miRNAs.

    Benefits and Drawbacks of Attending Medical Conferences for Interns
    QIN Hai-Qiang,ZHAO Xing-Quan, WANG Chun-Xue, et al.
    2013, 8(02):  159-160. 
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