关键词: 危险因素; 病因; 脑梗死

Abstract:

Objective To investigate the differences of risk factors and etiology among different age groups of youth and middle aged & elderly people. Methods A total of 148 cases of youth cerebral infarction inpatients were separated into two groups: 18 to 35 years old group and 36 to 45 years old group. And 232 cases of middle aged & elderly inpatients (older than 45 years) in the same period were collected as control group, the distribution of risk factors and stroke subtypes were compared statistically among groups. Results (1) In 18 to 35 years old group, the top three risk factors were hyperhomocysteinemia (HHcy) (66.7%), hyperlipemia (40.7%) and hypertension (33.3%). In 36 to 45 years old group, the three most frequent risk factors were hypertension (59.5%), HHcy (56.2%) and hyperlipemia (47.1%). In the elderly group, the three most common risk factors were hypertension (72.4%), HHcy (54.7%) and hyperlipemia (48.7%). (2) The frequencies of hypertension and diabetes in elderly group were observed to be higher than that in 18 to 35 years old group (P <0.001, P =0.014) and 36 to 45 years old group (P <0.001, P <0.001), which was lower in 18 to 35 years old group than in 36 to 45 years old group (P =0.009, P <0.001). The exposure of heavy smoking was significantly lower in 18 to 35 years old group than that in 36 to 45 years old group (P =0.006) and elderly group (P <0.001). (3) The proportion of undetermined etiology was highest in 18 to 35 years old group, significantly higher than in elderly group (37.0% vs 27.6%, P =0.013). The proportion of large artery atherosclerosis was highest in 36 to 45 years old group and elderly group (50.4% and 58.2%), were significantly higher

than that (25.9%) in 18 to 35 years old group (P =0.021, P =0.014). Conclusion Similar to the elderly group, the top three risk factors are hypertension, HHcy and hyperlipemia in 36 to 45 years old group, and large artery atherosclerosis is the leading cause of stroke. The difference is that HHcy, hyperlipemia and hypertension are the former three risk factors in 18 to 35 years old group, and most of patients are of unknown etiology

Key words: Risk factors; Etiology; Cerebral infarction