中国卒中杂志 ›› 2017, Vol. 12 ›› Issue (02): 192-198.DOI: 10.3969/j.issn.1673-5765.2017.02.020

• 综述 • 上一篇    下一篇

阿替普酶静脉溶栓后发生早期神经功能恶化的研究进展

崔颖,佟旭,王伊龙,郑华光,曹亦宾   

  1. 1063000 唐山华北理工大学研究生院
    2华北理工大学附属唐山市工人医院神经内科
    3首都医科大学附属北京天坛医院卒中临床试验与临床研究中心
  • 收稿日期:2016-09-26 出版日期:2017-02-20 发布日期:2017-02-20
  • 通讯作者: 曹亦宾 yibin07@sina.com
  • 基金资助:

    2016年北京市科学技术委员会“首都临床特色应用研究”专项课题(Z161100000516079)

Study Progress of Early Neurological Deterioration Following Intravenous Thrombolysis with Alteplase

  • Received:2016-09-26 Online:2017-02-20 Published:2017-02-20

摘要:

尽管多数急性缺血性卒中患者经阿替普酶静脉溶栓治疗后症状有所缓解,仍有相当一部 分患者经历早期神经功能恶化(early neurological deterioration,END),症状进一步加重。目前学术界 对于END的定义尚未统一,因此导致END的发生率不尽相同。关于END确切病因、危险因素以及相关 病理生理机制仍是学术界讨论的热点。END的发生强烈提示患者3个月预后不良。本文就以上内容进 行综述。

关键词: 急性缺血性卒中; 阿替普酶; 静脉溶栓; 早期神经功能恶化; 病因; 危险因素

Abstract:

Although the majority of patients with acute ischaemic stroke tends to improve after intravenous thrombolysis with alteplase, there are still certain portion of patients experiencing early neurological deterioration (END) with aggravated symptoms. The definition of END still haven’t been unified, so that there are differences of reported incidence. The precise causes and risk factors of END with clear underlying pathophysiology remain as the hotspot topic to be discussed. In this paper, all of above mentioned contents were reviewed.

Key words: Acute ischaemic stroke; Alteplase; Intravenous thrombolysis; Early neurological deterioration; Causes; Risk factors