中国卒中杂志 ›› 2017, Vol. 12 ›› Issue (09): 863-868.DOI: 10.3969/j.issn.1673-5765.2017.09.023

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环磷腺苷信号通路与血管重塑关系的研究进展

高飞,胡晓露,陈康宁   

  1. 400038 重庆重庆西南医院神经内科
  • 收稿日期:2016-12-06 出版日期:2017-09-20 发布日期:2017-09-20
  • 通讯作者: 陈康宁 ckn_640827@126.com

Research Progress of the Association between cAMP Signalling Pathway and Vascular Remodeling

  • Received:2016-12-06 Online:2017-09-20 Published:2017-09-20

摘要:

环磷腺苷(cyclic adenosine monophosphate,cAMP)信号通路作为一种重要的细胞内信息传 递系统参与调节了多种生物活动。近期研究发现,cAMP通路的激活可有效抑制心脑血管疾病进程中 的血管重塑,cAMP通路有望成为治疗上述疾病的新的靶目标。本文从cAMP通路抑制血管内皮炎症、 内膜增生和血小板异常激活等方面阐述cAMP信号通路与血管重塑的关系。

文章导读: 本文阐述了环磷腺苷信号通路调控病理性血管重塑的具体机制,以期为动脉粥样硬化和支架置入术后血管再狭窄的预防和治疗提供新的线索。

关键词: 血管重塑; 环磷酸腺苷; 内皮细胞; 平滑肌细胞; 血小板

Abstract:

Cyclic adenosine monophosphate (cAMP) signaling pathway, as an important intracellular messenger delivery system, is related to modulation of multiple physiological processes. Recent studies found that activated cAMP signaling pathway could suppress vascular remodeling involved in cardiovascular and cerebrovascular diseases and it might be expected to become new target for treatment of these diseases. This paper is to illustrate the association between cAMP signaling pathway and vascular remodeling from the aspect that cAMP signaling pathway may suppress vascular endothelial inflammation, intimal hyperplasia and blood platelets excessive activation.

Key words: Vascular Remodeling;Cyclic AMP; Endothelial Cells; Smooth Muscle Cells; Blood Platelets