关键词: 倾向性评分法; 临床研究; 脑血管病; 真实世界研究

Abstract: Real-world studies, originating from pragmatic clinical trials, evaluate the effectiveness and safety of interventions in real clinical practice, as a supplement for randomized controlled trials to evaluate the effectiveness of intervention measures in real clinical environment. However, the control of confounding factors is particularly important as this type of study lacks randomization. The propensity score method, which can adjust for multiple confounders/covariates, is an important analysis method for controlling confounders in real world studies. This article introduced four methods of propensity score and discussed their advantages and disadvantages; and introduced the application of propensity score method in the real-world research on cerebrovascular disease through case studies, combined with the characteristics of clinical research on cerebrovascular disease.

Key words: Propensity score; Clinical research; Cerebrovascular disease; Real-world study