1 Yang G，Wang Y，Zeng Y. Rapid health transition in

China，1990-2010：findings from the Global Burden

of Disease Study 2010[J]. Lancet，2013，381：1987-

2015.

2 Mozaffarian D，Benjamin EJ，Go AS，et al. Executive

Summary：Heart Disease and Stroke Statistics-2016

Update：A repor t f rom the Amer ican Hear t

Association[J]. Circulation，2016，133：447-454.

3 Teuschl Y，Matz K，Brainin M，et al. Prevention of

post-stroke cognitive decline：a review focusing on

lifestyle interventions[J]. Eur J Neurol，2013，20：35-

49.

4 Zheng Z，Yenari MA. Post-ischemic inflammation：

molecular mechanisms and therapeutic implications[J].

Neurol Res，2004，26：884-892.

5 Logani S，Chen MC，Tran T，et al. Actions of Ginkgo

Biloba related to potential utility for the treatment

of conditions involving cerebral hypoxia[J]. Life Sci，

2000，67：1389-1396.

6 Chandrasekaran K，Mehrabian Z，Spinnewyn B，et

al. Bilobalide，a component of the Ginkgo biloba

extract (EGb 761)，protects against neuronal death

in global brain ischemia and in glutamate-induced

excitotoxicity[J]. Cell Mol Biol，2002，48：663-669.

7 Nash K，Shah ZA. Current perspectives on the

beneficial role of ginkgo biloba in neurological and

cerebrovascular disorders[J]. Integr Med Insights，

2015，10：1-9.

8 Jiao YB，Rui YC，Li TJ，et al. Expression of proinflammatory

and anti-inflammatory cytokines in

brain of atherosclerotic rats and effects of Ginkgo

biloba extract[J]. Acta Pharmacol Sin，2005，26：835-

839.

9 Shen R，Xu Y，Zhang ZX，et a l . Ef fe c t of

electroacupuncture combined with Ginkgo biloba

extract (GBE 50) on learning-memory ability and

hippocampal cytokine levels in rats with dysmnesy[J].

Zhen Ci Yan Jiu，2009，34：329-333.

10 Ihl R，Tribanek M，Bachinskaya N，et al. Efficacy

and tolerability of a once daily formulation of Ginkgo

biloba extract EGb 761(R) in Alzheimer's disease

and vascular dementia：results from a randomised

controlled trial[J]. Pharmacopsychiatry，2012，45：41-

46.

11 Gerber J，Puetz V，Bodechtel U，et al. Endovascular

treatment of ischaemic stroke patients - new evidence

and old challenges[J]. Vasa，2016，45：267-274.

12 Saleem S，Zhuang H，Biswal S，et al. Ginkgo biloba

extract neuroprotective action is dependent on heme

oxygenase 1 in ischemic reperfusion brain injury[J].

Stroke，2008，39：3389-3396.

13 Shah ZA，Nada SE，Doré S，et al. Heme oxygenase

1，beneficial role in permanent ischemic stroke and

in Gingko biloba (EGb 761) neuroprotection[J].

Neuroscience，2011，180：248-255.

14 Nada SE，Shah ZA. Preconditioning with Ginkgo

biloba (EGb 761(R)) provides neuroprotection through

HO1 and CRMP2[J]. Neurobiol Dis，2012，46：180-189.

15 Jiang M，Li J，Peng Q，et al. Neuroprotective

effects of bilobalide on cerebral ischemia and

reperfusion injury are associated with inhibition of

pro-inf lammatory mediator production and down

regulation of JNK1/2 and p38 MAPK activation[J]. J

Neuroinflammation，2014，11：167.

16 Na d a SE，Tulsulkar J，Shah ZA，et al. Heme

oxygenase 1-mediated neurogenesis is enhanced by

Ginkgo biloba (EGb 761(R)) after permanent ischemic

stroke in mice[J]. Mol Neurobiol，2014，49：945-956.

17 Har rington LE，Hatton RD，Mangan PR，et al.

Interleukin 17-producing CD4+ effector T cells

develop via a lineage distinct from the T helper type 1

and 2 lineages[J]. Nat Immunol，2005，6：1123-1132.

18 Park H，Li Z，Yang XO，et al. A distinct lineage

of CD4 T cells regulates tissue inf lammation by

producing interleukin 17[J]. Nat Immunol，2005，6：

1133-1141.

19 Waisman A，Hauptmann J，Regen T. The role of IL-

17 in CNS diseases[J]. Acta Neuropathol，2015，129：

625-637.

20 Kao CY，Chen Y，Thai P，et al. IL-17 markedly upregulates

beta-defensin-2 expression in human

airway epithelium via JAK and NF-kappaB signaling

pathways[J]. J Immunol，2004，173：3482-3491.

21 Khader SA，Bell GK，Pearl JE，et al. IL-23 and IL-

17 in the establishment of protective pulmonary

CD4+ T cell responses after vaccination and during

Mycobacter ium tuberculosis challenge[J]. Nat

Immunol，2007，8：369-377.

22 Kostulas N，Pelidou SH，Kivisäkk P，et al. Increased

IL-1beta，IL-8，and IL-17 mRNA expression in blood

mononuclear cells observed in a prospective ischemic

stroke study[J]. Stroke，1999，30：2174-2179.

23 Li HL，Kostulas N，Huang YM，et al. IL-17 and IFNgamma

mRNA expression is increased in the brain

and systemically after permanent middle cerebral

artery occlusion in the rat[J]. J Neuroimmunol，2001，

116：5-14.

24 Zhang J，Mao X，Zhou T，et al. IL-17A contributes

to brain ischemia reperfusion injury through calpain-

TRPC6 pathway in mice[J]. Neuroscience，2014，274：

419-428.

25 Gelderblom M，Weymar A，Bernreuther C，et al.

Neutralization of the IL-17 axis diminishes neutrophil

invasion and protects from ischemic stroke[J]. Blood，

2012，120：3793-3802.

26 Wright CB，Sacco RL，Rundek T，et al. Interleukin-6

is associated with cognitive function：the Northern

Manhattan Study[J]. J Stroke Cerebrovasc Dis，2006，

15：34-38.

27 Doecke JD，Laws SM，Faux NG，et al. Bloodbased

protein biomarkers for diagnosis of Alzheimer

disease[J]. Arch Neurol，2012，69：1318-1325.

28 Chen JM，Jiang GX，Li QW，et al. Increased serum

levels of interleukin-18，-23 and -17 in Chinese

patients with Alzheimer's disease[J]. Dement Geriatr

Cogn Disord，2014，38：321-329.