关键词: 颈动脉; 狭窄; 血管造影; 血液动力学; 兔

Abstract: Objective To establish a carotid stenosis model which is convenient for evaluating the hemodynamics of stenosis arteries.Methods By using suture, we bound the carotid arteries with plastic tubes in different calibers to establish the carotid stenosis model in various degrees, and then to evaluate the stenosis with digital subtraction angiography (DSA) and the hemodynamics with transcranial Doppler sonography (TCD).Results In the DSA results(CCA criterion), the light was 30%, the moderate 59%, the severe 84%; In TCD results, we could clearly detect the hemodynamics before and after establishing the models and the pulsatility index(PI) and resistance index(RI) both reduced after establishing the models except the proximal of the severe. But in all models we could find that in the proximal of stenosis the blood velocity reduced and the PI and RI increased; in the spot of stenosis, the blood velocity increased while the PI and RI reduced; in the distal of stenosis, the blood velocity, PI and RI also reduced.Conclusion Using our method we can establish a stenosis model quickly, stably and the hemodynamics are convenient to be detected. These models are more ideal to evaluate the hemodynamics in the carotid stenosis.

Key words: Carotid artery; stenosis; Angiography; Hemodynamics; Rabbit