关键词: 烟雾病; 局部血流; 超声检查; 多普勒; 经颅; 颅骨多点钻孔术

Abstract: Objective Using multicolor ultraphonic power Doppler to study the hemodynamic change of childhood moyamoya disease after multiple burr-hole operation, to know the effectiveness of the multiple burr-hole operation and to choose the best device of follow-up. Methods Eight children diagnosed with moyamoya disease underwent multiple burr-hole operations. And we used multicolor ultraphonic power Doppler assisting with single photon emission computed tomography (SPECT) to observe the hemodynamic change before and after the operations. Results Beginning at one week after operation, angiograms showed neovascularization, and 3 months after operation showed rich neovascularization. SPECT showed that the regional cerebral blood flow(rCBF) of homolateral hemisphere was improved at 3 months after burr-hole operation, but rCBF of opposite hemisphere decreased when compared with preoperation. Ischemic symptoms of all the patients improved after burr-operation. Conclusion After burr-hole operation, we can find rich new vessels and lateral branches through the holes. The burr-hole operation can improve the ischemia of childhood moyamoya disease; Doppler imaging is a valid noninvasive alternative to carotid artery angiography in evaluating direct and indirect revascularization.

Key words: Moyamoya disease; Regional blood flow; Ultrasonography; doppler; transcranial; Burr-hole operation