关键词: 脑出血; 脑状态指数; 意识; 刺激

Abstract: Objective To test whether cerebral state index(CSI) can be used as measurement of level of consciousness in intracranial hemorrhage patients and to investigate the influence of external stimuli on CSI values.Methods Twenty-one adult intracranial hemorrhage patients were enrolled consecutively, and 77 separate sessions were assessed. After CSI monitoring was set up, patient’s motor responses to verbal or painful stimuli in Glasgow Coma Scale(GCS-M) were assessed. CSI values were recorded for 10min before and after external stimulation. Purposeful movement in response to stimuli was defined by GCS-M levels of 5-6. Prediction probability(PK) was calculated for CSI in predicting purposeful movement to external stimuli. The values of CSI associated with a probability of 5% and 95% fordetecting purposeful movement to external stimuli (CSI5% and CSI95%) were also estimated.Results CSI values increased significantly after verbal or painful stimulation, from 54±18 to 68±20 (P <0.001). CSI significantly correlated with GCS-M, and Spearman correlation coefficients were 0.63 and 0.84, between GCS-M and CSI before and after stimulation, respectively(P <0.01). CSI showed ahigh prediction probability for detecting purposeful movement to external stimuli, with 0.86 in before stimulation value and 0.98 in stimulated value.Conclusion CSI might be a valid measurement of consciousness in intracranial hemorrhage patients.CSI values after external stimulations were more reliable in detecting purposeful movement in response to external stimuli.

Key words: Hemorrhage cerebral; Cerebral state index; Consciousness; Stimulation