关键词: 颅内动静脉畸形; 出血; 基质金属蛋白酶-9; 基质金属蛋白酶类组织抑制剂; 免疫组织化学

Abstract: Objective To examine the expression of matrix metalloproteinase-9 (MMP-9) and tissue inhibitors of metalloproteinase1(TIMP-1) in cerebullar arteriovenous malformations (CAVM) and their relationship with hemorrhagic history in CAVM.Methods 48 patients who suffered with CAVM were studied, including 24 patients with hemorrhagic history (CAVM H group) and 24 patients without hemorrhagic history (CAVM N group). 24 patients suffered with essential epilepsy were control group (CG). All of the patients admitted during May 2007-September 2008 and were given operation. We studied their history,clinical symptom and radiologic manifestation. examined the expression of MMP-9, TIMP-1 in patients brain tissue by immunohistochemistry.Results Compared with control samples, CAVM samples had higher levels of MMP-9, TIMP-1(P <0.01).There was no significant difference in levels of MMP-9, TIMP-1(P >0.05) between CAVM H Group and CAVM N Group, But, Compared with CAVM N Group, CAVM H Group had higher levels of MMP-9/TIMP-1(P <0.05).Conclusion ①Maybe MMP-9 is a essential factor lead to structural instability, growth and abnormal extension of vessels in CAVMs. MMP-9 is one of the factors to promote expression of TIMP-1. ②MMP-9 can lead hemorrhage in CAVMs, as the endogenous specific inhibitor of MMP-9, TIMP-1 is a protective factor to prevent hemorrhage in CAVMs.Perhaps disbalance ofMMP-9 and TIMP-1, MMP-9 is higher relatively is a important reason of hemorrhage in CAVMs.

Key words: Intracranial arteriovenous malformations; Hemorrhage; Matrix metalloproteinase 9; Tissue inhibitor of metalloproteinases; Immunohistochemistry