›› 2009, Vol. 4 ›› Issue (12): 951-955.

• 论著 • 上一篇    下一篇

人血白蛋白在治疗急性重症缺血性卒中中的疗效观察

孙奉辉,李淑娟,刘岳阳,杨磊,胡文立   

  1. 北京市首都医科大学附属北京朝阳医院神经内科
  • 收稿日期:2009-08-02 修回日期:2009-07-02 出版日期:2009-12-20 发布日期:2009-12-20
  • 通讯作者: 胡文立

Observation of the Effect of Human Albumins in Acute Severe Cerebral Infarction Patients

SUN Feng-Hui, LI Shu-Juan, LIU Yue-Yang, et al.   

  • Received:2009-08-02 Revised:2009-07-02 Online:2009-12-20 Published:2009-12-20
  • Contact: HU Wen-Li

摘要: 目的 观察人血白蛋白治疗急性重症缺血性卒中的疗效。方法 收集急性重症缺血性卒中患者80例,分为两组。治疗组44例,在常规治疗的基础上加用20%人血白蛋白50ml静脉滴注2次/d,连用5d,之后酌情间断应用;对照组36例,仅在血清白蛋白低于25g/L时加用人血白蛋白。比较治疗前、治疗2周后两组间神经功能缺损程度评分和Glasgow昏迷评分的变化,以及治疗期间两组间并发症的发生率。结果 治疗组神经功能缺损评分明显低于对照组(P<0.05),而Glasgow昏迷评分明显高于对照组(P<0.05);治疗组肺部感染、肾功能不全、应激性溃疡、低蛋白血症等并发症的发生率均明显低于对照组(P<0.05)。结论 人血白蛋白治疗急性重症缺血性卒中的疗效显著,且能降低重症缺血性卒中患者并发症的发生率。

关键词: 脑梗死; 白蛋白; 治疗结果; 并发症

Abstract: Objective To appraise the effect of Human Albumins in the acute severe cerebral infarction patients.Methods Eighty acute severe cerebral infarction patients were divided into 2 groups. Conventional therapy was applied in the 2 groups, and Human Albumins was used conventionally in treatment group(n=44), whereas it was used in control group(n=36) only when serum albumin was less than 25g/L. Following treatment for 2 weeks, Scandinavian Stroke Scale and Glasgow Coma Scale were evaluated, and the incidence of complications was compared in the 2 groups.Results After treatment, clinical neurologic impairment score of treatment group was significantly lower than that of control group(P<0.05). Coma scale of treatment group was significantly higher than that of control group(P<0.05). The incidence of complications, such as pulmonary infection, renal dysfunction, stress, ulcer and hypoproteinemia, was all higher than that of control group(P<0.05).Conclusion Human Albumins was significant effective for acute severe cerebral infarction patients and could decrease the incidence of complications of severe cerebral infarction patients.

Key words: Brain infarction; Albumins; Treatment outcome; complication