关键词: 氧; 面罩; 脑梗死; 血气分析

Abstract: Objective To investigate the safety and gas analysis after continuous usage of hyperoxygenationin severe ischemic stroke patients.Methods According to the methodology of our prior study, we included 16 severe ischemic strokepatients within 48 hours of onset from August, 2005 to February, 2007; by means of 2:1 (Maskto cannula) randomization. Both groups were allocated to use mask or cannula for 10 days at oneatmosphere. Inclusion criteria were changed to National Institute of Health Stroke Scale(NIHSS)score 17 and more than two-third of middle cerebral artery(MCA) territory infarction. . Overallarterial blood gases were recorded at six o'clock a.m. in the initial, day 1 and day 10 after patientsregistered. Concomitant treatments were as clinical practice.Results During 18 months, 16 severe infarction patients were enrolled in 57 MCA infarctions.There were 11 patients allocated to the venturi mask and 5 to the cannula group randomly. Theywere basically equal. There were no statistical difference at both artery blood gas analysis andAPACHE II scores in survival patients in the initial, day 1 and day 10; NIHSS scores were 22initially and 16 at discharge in both groups. However, confounding factors such as craniectomyand hyperventilation might contribute to the survival outcomes.Conclusion This pilot study sought to find if gas profiles contribute to the survival outcomes.No statistical difference in gas analysis, APACHE II and survival outcomes. Incomplete data collections and confounders might contribute to the survival outcomes which need to be clarifiedin the future large sample size study.

Key words: Oxygen; Masks; Brain infarction; Biood gas analysis