关键词: 抑郁; 卒中后; WHO-CIDI; 危险因素; mRS

Abstract: Objective To examine the incidence, demographic factors and clinical determinants of post-strokedepression (PSD) within 3 months after stroke (including cerebral infarction and intracerebralhemorrhage).Methods Those patients who were hospitalized for acute cerebrovascular diseases (includingcerebral infarction and intracerebral hemorrhage) within 14 days after the index stroke onset fromApril 2008 to December 2009 were screened. The following patient information was collected:demographics; clinical data [including the National Institute Of Health Stroke Scale (NIHSS),modified Rainkin Scale (mRS) and mini mental status examination (MMSE)]. At 90-day follow upafter stroke, the diagnosis of depression was considered by World Health Organization CompositeInternational Diagnostic Interview 3.0 (WHO-CIDI 3.0) based on Diagnostic and Statistical Manualof Mental Disorders-IV (DSM-IV).Results The 3-month cumulative incidence of PSD was 29% (n=91) in this patient population,with 24.2% patients (n=76) diagnosed with major depression and 4.8% (n=15) diagnosed withminor depression. In univariate analysis, the percentage of female patients and patients with pasthistory of depression were significantly higher in PSD group than in non-PSD group (all P <0.01,respectively). The severity of stroke (NIHSS) at 14 days and the level of disability (mRS) at 14 daysas well as at 90 days after stroke were significantly higher in PSD group than in non-PSD group (all P <0.01). Multivariate analysis showed that female gender [Odds ratio (OR):2.178, 95% confidenceinterval (CI):1.219～3.892, P <0.01], history of depression(OR :5.762, 95%CI : 2.958～11.223,P <0.01) and level of handicap at 14 days after stroke (OR :1.520, 95%CI :1.212～1.907, P <0.01) arethree independent clinical risk factors of PSD.Conclusion The 3-month cumulative incidence of PSD was 29% which suggested PSD is acommon complication of stroke and should be attached great importance. Female gender, history ofdepression and level of handicap at 14 days after stroke are three independent risk factors of PSDduring the first 3 months after stroke.

Key words: Depression; post-stroke; WHO-CIDI; Risk factors; mRS