›› 2010, Vol. 5 ›› Issue (11): 899-903.

• 论著 • 上一篇    下一篇

对颈动脉粥样硬化溃疡斑块内超声造影的定量研究

徐斌1,张丹2,刘兴洲1,伍文清3,孟焱,翟林2,黄光1,李卫东1,康更洁1,黄碧波1   

  1. 1北京市首都医科大学附属复兴医院神经内科2首都医科大学附属复兴医院超声影像科3首都医科大学附属友谊医院神经内科
  • 收稿日期:2010-04-25 修回日期:2010-03-25 出版日期:2010-11-20 发布日期:2010-11-20
  • 通讯作者: 徐斌

Contrast-Enhanced Ultrasonography for the Detection of Ulcerated Plaques with Neoangiogenesis in Carotid Artery

XU Bin*, ZHANG Dan, LIU Xing-Zhou, et al.   

  • Received:2010-04-25 Revised:2010-03-25 Online:2010-11-20 Published:2010-11-20
  • Contact: XU Bin

摘要: 目的 了解颈动脉粥样硬化溃疡斑块内新生血管的血流动力学定量特点。方法 将颈动脉粥样硬化易损斑块患者按有无临床缺血症状分为症状组与非症状组,比较两组患者溃疡斑块发生率;对易损斑块进行超声造影检查,比较溃疡斑块和非溃疡斑块的造影剂到达时间、达峰时间、斑块内新生血管增强密度和斑块峰值强度/颈动脉管腔峰值强度比值差异。分析两组斑块血流动力学特点及斑块内新生血管的定量特征。结果 入组41例患者,共有48个易损斑块。症状组溃疡斑块发生率为68.2%,无症状组溃疡斑块发生率为38.5%,差异有统计学意义(P <0.05)。超声造影检查显示溃疡斑块组造影剂到达时间、斑块内新生血管增强密度和斑块峰值强度/颈动脉管腔峰值强度比值较非溃疡斑块组差异有统计学意义(7.21±2.17 s vs 10.32±3.17 s,P <0.05;15.1±6.4 dB vs 11.3±5.1 dB,P <0.05;0.64±0.17 vs 0.47±0.21,P <0.05)。结论 缺血症状组溃疡斑块的发生率较高;溃疡斑块组的新生血管密度高于非溃疡斑块组。

关键词: 颈动脉疾病; 动脉硬化; 新生血管化; 病理性; 超声检查; 造影剂

Abstract: Objective To observe and quantitative analysis neoangiogenesis within ulcerated plaques anddetermine the correlation between the ulcerated plaques enhancement and clinical symptoms inpatients with contrast-enhanced ultrasonography angiography in carotid atherosclerotic plaques.Methods Fourty-eight plaques of 41 patients with soft plaque and/or mixed plaque were studiedwith standard and contrast–enhanced ultrasonography. Contrast enhancement in the ulceratedplaque was evaluated with visual interpretation and quantitative analysis.Results Arrive time (7.21), enhanced intensity in the plaque (15.1) and the ratio of enhancedintensity in the plaque to that in the lumen of the carotid artery (0. 64) in symptomatic patientswere significantly greater than those in asymptomatic patients (P <0.05, respectively).Conclusion The incidence of ulcerated plaques in symptomatic patients is higher than that ofasymptomatic patients; The density of angiogenesis in ulcerated plaques is higher than that ofnon-ulcerated plaques.

Key words: Carotid artery diseases; Arteriosclerosis; Neovascularization; pathologic; Ultrasonography; Contrast media