关键词: 脑梗死; C反应蛋白质; 白细胞介素6

Abstract: Objective To investigate the early time course of plasma high sensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6) level after acute ischemic stroke and the relationship with clinicalcharacters and outcome.Methods Serial enrollment of acute ischemic stroke patients (n=47) and healthy controls (n=40).We compared the serial measurements of plasma hs-CRP and IL-6 level of acute ischemic strokepatients with that of healthy controls, and analyzed their dynamic variation rules. Patients weredivided into mild stroke (n=15) and severe stroke (n=32) group according to national institutes ofhealth stroke scale (NIHSS). We compared the plasma level of hs-CRP and IL-6 of the two groups,and also that of the patients with good and poor outcome.Results There was no difference of plasma hs-CRP at 3h between stroke patients and healthycontrols, but was significantly higher in stroke patients at 6h (P =0.01), 12h (P =0.01), 24h (P <0.01),48h (P <0.01), 3d (P <0.01) and 7d (P <0.01) than controls. Plasma IL-6 of stroke patients at eachtime points was significantly higher than that of the controls (P <0.01). Hs-CRP level of severestroke patients was significantly higher than mild ones at 12h, 24h, 48h, 3d and 7d (P =0.046, 0.012,0.030, 0.007 and 0.041, respectively). The same was also true for IL-6 at those time points (P =0.002,0.001, 0.006, 0.026 and 0.043, respectively). There was no difference of plasma hs-CRP and IL-6level between patients with good and poor outcome.Conclusion Plasma hs-CRP and IL-6 levels elevated after acute ischemic stroke, and correlatedwith clinical severity.

Key words: Brain infarction; C-reactive protein; Interleukin-6