关键词: 丁苯酞; 马来酸桂哌齐特; 脑梗死; 治疗

Abstract: Objective To study the curative effect and safety of dl-3-budylphthalinde and cinepazidemaleate on acute cerebral infarction.Methods One hundred and sixty patients with acute cerebral infarction were divided into four groups continuously and randomly:combination therapy group(40cases), budylphthalinde group(40cases), dl-3-budylphthalinde group(40cases) and conventional treatment group(40cases). Neural function defect and activity of daily living were tested by National Institutes of Health Stroke Scale(NIHSS) and Barthel Index(BI) before therapy and after two weeks and six month treatment. Adverse events were statistically analyzed.Results NIHSS total score after two weeks treatment, Compared with conventional treatment group, budylphthalinde group or dl-3-budylphthalinde used alone has no statistical significance(P>0.05), but there was synergy between the two drugs(P<0.01). BI after two weeks treatment, budylphthalinde group or dl-3-budylphthalinde used alone has statistical significance (P=0.029, P=0.002), but combination therapy group has better effect(P=0.001). NIHSS total score and BI after six month treatment, budylphthalinde group or dl-3-budylphthalinde used alone or combination therapy has significant curative effect(P<0.01), and combination therapy group has better effect. The 1 case in therapy group, 2 cases in dl-3-budylphthalinde group, 1 case in conventional treatment group appeared upset stomach. Symptoms improved after symptomatic treatment.Conclusion There was synergy between l-3-budylphthalinde combined with cinepazidemaleate. Itis an effective and safe method to treat acute cerebral infarction by the two drugs.

Key words: Dl-3-budylphthalinde; Cinepazidemaleate; Brain infarction; Treatment