关键词: 短暂性脑缺血; 沙土鼠; 牛磺酸; 缺血大脑保护

Abstract: Objective To investigate the protection of taurine against transient forebrain ischemia in gerbils.Methods The model of transient forebrain ischemia in gerbil was induced through ligating bilateral carotid arteries for 5 min. The dose of 2.5, 5, 15 or 50 mg/kg of taurine was administrated intravenously 1 h after ischemia. The behavior and the neuronal death in hippocampal CA1 region were evaluated 7 days after induction of ischemia.Results Treatment with 2.5 mg/kg of taurine improved gerbil behavior and reduced the neuronal death in hippocampal CA1 region, although it did not reach statistical significance. Taurine at dose of 5, 15 or 50 mg/kg improved gerbil behavior(P=0.001, 0.006, and 0.037, respectively), and reduced the neuronal death in hippocampal CA1 region significantly(all P=0.0001). Moreover, the efficacies of 5, 15, and 50 mg/kg of taurine were better than that of 2.5 mg/kg of taurine(P=0.001, 0.001, and 0.005, respectively).Conclusions Taurine attenuates the brain damage due to transient forebrain ischemia in a dose-dependent manner, suggesting that taurine is an efficacious neuroprotectant.

Key words: Transient brain ischemia; Taurine; Gerbil; Neuroprotection