关键词: 急性脑血管病; 脑出血; 脑梗死; 短暂性脑缺血发作; 凝血; 纤溶

Abstract: Objective To explore the change of some factors tissue-type plasminogen activator(t-PA) and plasminogen activator inhibitor-1(PAI-1) in the patients with acute cerebrovascular disease and to provide some theorical evidences for the clinical treatment.Methods The level of t-PA, PAI-1 antigen in the 78 patients with acute cerebral hemorrhage, cerebral infarction and transient ischemic attack(TIA) was determined by enzyme-linked immunosorbnent assay(ELISA) from October 2007 to September 2008. These data were compared with control group, which contains 22 patients.Results To the cerebral hemorrhage, the level of t-PA of experimental group was higher than those of the control group(P<0.001). The level of PAI-1 antigen was lower than those of the control group(P<0.001). The differences between the experimental group and the control group were significant. To the cerebral infarction, the level of t-PA and PAI-1 antigen of experimental group was higher than those of the control group(P<0.001). In TIA, the level of PAI-1 antigen in experimental group was higher than those in control group(P<0.001). The level of t-PA was lower(P=0.006). The differences between the experimental group and the control group were significant(P<0.001).Conclusion To the patients with acute cerebrovascular diseases, there is disturbance of blood coagulation, anticoagulation and fibrolysis.

Key words: Acute cerebrovascular disease; Cerebral hemorrhage; Cerebral infarction; Transient ischemic attack; Coagulation; Fibrolysis