关键词: 骨髓增殖性疾病; 血栓形成; 高白细胞; JAK2V617F基因; 年龄

Abstract: Objective To retrospectively analyse the thrombotic risk factors of myeloproliferative disorders.Methods We collected data from 107 cases of patients with essential thrombocytosis(ET) and polycythemia vera(PV), including 65 patients with thrombosis from Beijing Aerospace General Hospital and Beijing Tiantan Hospital affiliated to Capital Medical University since August 2007 to February 2012. Clinical characteristics and laboratory data(history, age, leukocyte count,JAK2V617F mutation and bone marrow assay) were reviewed and analyzed by multivariate logistic regression analysis.Results The population consisted of 43 women and 64 men with ages ranging from 28 to 84 years.Sixty five patients had thrombosis concomitantly, including 34 ischemic cerebrovascular incidents.The leukocytes was over 11.0×109/L for 41 patients(63.1%) and mutation JAK2V617F was found for 39 patients(60.0%) in those thrombotic events. These two rates were higher than those ofpatients group with non-thrombosis. The number of patients with age over 60 also increased in thrombotic patients. Multivariate logistic regression analysis showed leukocytosis([odds ratio,OR]3.393, P＜0.05), mutation JAK2V617F (OR 3.104, P＜0.05) and over 60 years(OR 2.523, P＜0.05) were the risk factors of thrombosis.Conclusion Leukocytosis, mutation JAK2V617F and over 60 years are the independent risk factors of myeloproliferative disorders with thrombosis, especially in ischemic stroke.

Key words: Myeloproliferative disorders; Thrombosis; Leukocytosis; JAK2V617F; Age