高压氧治疗儿童缺血型烟雾病疗效分析

中国卒中杂志 ›› 2013, Vol. 8 ›› Issue (12): 959-964.

高压氧治疗儿童缺血型烟雾病疗效分析

刘亚玲1，张红霞1，于秋红1，薛连璧1，邓亚仙2

1100050 北京
首都医科大学附属北京
天坛医院高压氧科
2首都医科大学附属北京
天坛医院儿科

收稿日期:2013-03-11 出版日期:2013-12-20 发布日期:2013-12-20
通讯作者: 薛连璧 xue_40@vip.sina.com

Effect of Hyperbaric Oxygen Therapy on Moyamoya Disease in Children

*Department
of Hyperbaric Oxygenation, Beijing Tiantan Hospital, Capital Medical University, Beijing
100050, China.

Received:2013-03-11 Online:2013-12-20 Published:2013-12-20

摘要/Abstract

摘要：

目的观察高压氧治疗儿童缺血型烟雾病的疗效及影响因素。方法连续收治以脑梗死为表现的儿童烟雾病患者，根据治疗方法分为高压氧组50例和对照组40 例，应用改良Rankin量表（modified Rankin Scale，mRS）对患者发病90 d的神经功能进行评价，比较两组的疗效。对高压氧组应用多因素Logistic回归方法分析影响疗效的因素。结果高压氧组发病90 d mRS评分低于对照组（P =0.004）。多因素Logistic回归分析显示高压氧治疗次数是高压氧组疗效的影响因素［比值比（odds ratio，OR）0.780；95%可信区间（confidence interval，CI） 0.675～0.901；P =0.001］。结论高压氧治疗儿童缺血型烟雾病有效，高压氧治疗次数是高压氧组疗效的影响因素。

文章导读： 本研究在国内首次对高压氧治疗儿童缺血型烟雾病的疗效进行了前瞻性对照研究，结果显示高压
氧治疗有效，而且其治疗效果与次数有关。

关键词: 高压氧; 烟雾病; 脑梗死; 儿童

Abstract:

Objective To investigate the effect of hyperbaric oxygenation therapy (HBOT) on cerebral infarction after moyamoya disease (MMD) in children and its risk factors. Methods Pediatric patients with MMD admitted to Beijing Tiantan Hospital from May 2006 to March 2013 were prospectively studied. Ninety patients were divided into HBOT group (50 cases) and control group (40 cases). Neurologic assessments were performed on the 90th day after onset. Multivariate Logistic regression analysis was used to analyze the risk factors of treatment effect in the HBOT group. Results Modified Rankin Scale (mRS) of the 90th day after onset in the HBOT group was lower than the control group (Z =-2.882, P =0.004). The risk factor associated with treatment effect in the HBOT group was frequency of HBOT (odds ratio [OR] 0.780; 95% confidence interval [CI] 0.675~0.901; P =0.001). Conclusion HBOT is useful in cerebral infarction after moyamoya disease. Frequency of HBOT is associated with treatment effect in the HBOT group.

Key words: Hyperbaric oxygenation; Moyamoya disease; Cerebral infarction; Children

刘亚玲1，张红霞1，于秋红1，薛连璧1，邓亚仙2. 高压氧治疗儿童缺血型烟雾病疗效分析[J]. 中国卒中杂志, 2013, 8(12): 959-964.

LIU Ya-Ling*, ZHANG Hong-Xia, YU Qiu-Hong, XUE Lian-Bi, DENG Ya-Xian.. Effect of Hyperbaric Oxygen Therapy on Moyamoya Disease in Children[J]. Chinese Journal of Stroke, 2013, 8(12): 959-964.

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