中国卒中杂志 ›› 2014, Vol. 9 ›› Issue (04): 294-302.

• 专题综述 • 上一篇    下一篇

个体化静脉溶栓治疗的研究进展

赵秋云1,丁红2,徐运1   

  1. 1210008 南京
    南京大学医学院附属鼓
    楼医院神经科
    2南京医科大学第二附属
    医院神经科
  • 收稿日期:2013-11-12 出版日期:2014-04-20 发布日期:2014-04-20
  • 通讯作者: 徐运 xuyun20042001@aliyun. com

Research Progress of Individualized Intravenous Thrombolysis with Recombinant
Tissue Plasminogen Activator

  • Received:2013-11-12 Online:2014-04-20 Published:2014-04-20

摘要:

缺血性卒中严重影响着人类的生活。静脉重组组织型纤溶酶原激活剂(intravenou s recombinant tissue plasminogen activator,rt-PA)溶栓治疗是目前被循证医学证明缺血性卒中急性期唯 一有效的方法。然而,在临床实施中,存在一些问题,如时间窗问题、伴随意识障碍问题、年龄问题、 剂量问题等等,提示在规范的基础上需进行个体化治疗,从而提高溶栓的有效性和安全性。本文就 静脉溶栓中涉及个体化方案临床研究的最新进展做一综述。

文章导读: 本文对影响静脉重组组织型纤溶酶原激活剂溶栓个体化治疗方案制定的因素进行了介绍,阐述了急
性缺血性卒中患者合并其他疾病、具有出血转化高危因素、轻型或重型卒中、超出时间窗、基底动脉
闭塞等特殊情况下溶栓治疗的研究进展。

关键词: 静脉溶栓; 卒中; 个体化

Abstract:

Ischemic stroke has a serious impact on human life. It has been proven that intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) is currently the only effective therapy for acute ischemic stroke by evidence-based medicine. However, some questions appear when doctors make prescription, such as narrow time window, with decreased level of consciousness, age, dosage of rt-PA. It suggests that individual therapy should be taken based on standard guide that could increase the efficacy and safety on the thrombolysis. Here, we review the latest developments of intravenous thrombolysis involving individualized clinical studies.

Key words: Intravenous thrombolysis; Stroke; Individualized