中国卒中杂志 ›› 2014, Vol. 9 ›› Issue (12): 1015-1019.

• 专题综述 • 上一篇    下一篇

脑微出血和认知障碍的研究进展

戴若莲,李焰生   

  1. 200127 上海
    上海交通大学医学院附
    属仁济医院神经内科
  • 收稿日期:2014-07-01 出版日期:2014-12-20 发布日期:2014-12-20
  • 通讯作者: 李焰生 lliyans@hotmail.com

Advances of Cerebral Microbleeds and Cognition Impairment

  1. Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of
    Medicine, Shanghai 200127, China
  • Received:2014-07-01 Online:2014-12-20 Published:2014-12-20

摘要:

脑微出血作为脑小血管病的一种影像学标志,与认知功能障碍的关系日渐受到关注。目前 临床研究发现微出血广泛存在于正常人群以及脑血管疾病或神经变性疾病引起认知障碍的患者,进 一步研究认为微出血可能是引起认知障碍的独立危险因素,主要影响执行功能,其数量与认知障碍 呈正相关。本文对其展开综述,并简要阐述了微出血可能引起认知障碍的发病机制,可能为临床治疗 或延缓高危人群的认知衰退提供帮助。

文章导读: 本文简单介绍了脑微出血的影像学特点,重点阐述其和各种类型认知障碍的相关性及可能的作用
机制。

关键词: 脑微出血; 认知障碍; 血管性认知障碍; 阿尔茨海默病

Abstract:

Cerebral microbleed (CMB), as an imaging sign of small vascular disease, has gradually gained people's attention because of the correlation with cognitive impairment. Current clinical research found that CMB widely existed in healthy people and cerebrovascular or neurodegenerative patients with cognitive impairment. The further studies indicated that CMB might be an independent risk factor for cognitive impairment, and especially impaired executive function. The numbers of CMB were positively correlated with cognitive impairment. We reviewed the previous studies, and briefly introduced the inner pathological mechanisms, which may help treat or delay cognitive decline in high-risk patients.

Key words: Cerebral microbleed; Cognitive impairment; Vascular cognitive impairment;
Alzheimer's disease