1 Greenberg SM, Vernooij MW, Cordonnier C, etal. Cerebral microbleeds:a guide to detection andinterpretation[J]. Lancet Neurol, 2009, 8:165-174.2 Cordonnier C. Brain microbleeds:more evidence, butstill a clinical dilemma[J]. Curr Opin Neurol, 2011,24:69-74.3 Vernooij MW, Ikram MA, Wielopolski PA, et al.Cerebral microbleeds:accelerated 3D T2*-weightedGRE MR imaging versus conventional 2D T2*-weighted GRE MR imaging for detection[J]. Radiolgy,2008, 248:272-277.4 Nandigam RN, Viswanatham A, Delgado P, et al. MRimaging detection of cerebral microbleeds:effect ofsusceptibility-weighted imaging, section thickness,and field strength[J]. AJNR Am J Neuroradiol, 2009,30:338-343.5 Wardlaw JM, Smith C, Dichgans M. Mechanisms ofsporadic cerebral small vessel disease:insights fromneuroimaging[J]. Lancet Neurol, 2013, 12:483-497.6 Vernooij MW, van der Lugt A, Ikram MA, et al.Prevalence and risk factors of cerebral microbleeds:theRotterdam Scan Study[J]. Neurology, 2008, 70:1208-1214.7 Poel s MM, Ve r nooij MW, I k r am MA, e t a l .Prevalence and risk factors of cerebral microbleeds:anupdate of the Rotterdam scan study[J]. Stroke, 2010,41:S103-106.8 Wer ring DJ. Cerebral microbleeds:clinical andpathophysiological significance[J]. J Neuroimaging,2007, 17:193-203.9 Jeerakathil T, Wolf PA, Beiser A, et al. Cerebralmicrobleeds:prevalence and associations withcardiovascular risk factors in the FraminghamStudy[J]. Stroke, 2004, 35:1831-1835.10 Yakushiji Y, Nishiyama M, Yakushiji S, et al. Brainmicrobleeds and global cognitive function in adultswithout neurological disorder[J]. Stroke, 2008,39:3323-3328. 11 Qiu C, Cotch MF, Sigurdsson S, et al. Cerebralmicrobleeds, retinopathy, and dementia:the AGESReykjavikStudy[J]. Neurology, 2010, 75:2221-2228.12 Poels MM, Ikram MA, van der Lugt A, et al. Cerebralmicrobleeds are associated with worse cognitivefunction:the Rotterdam Scan Study[J]. Neurology,2012, 78:326-333.13 Hilal S, Saini M, Tan CS, et al. Cerebral microbleedsand cognition:the epidemiology of dementia inSingapore study[J]. Alzheimer Dis Assoc Disord,2014, 28:106-112.14 Cordonnier C, Al-Shahi SR, Wardlaw J, et al.Spontaneous brain microbleeds:systematic review,subgroup analyses and standards for study design andreporting[J]. Brain, 2007, 130:1988-2003.15 Seo SW, Hwa Lee B, Kim EJ, et al. Cl inicalsignificance of microbleeds in subcortical vasculardementia[J]. Stroke, 2007, 38:1949-1951.16 Werring DJ, Frazer DW, Coward LJ, et al. Cognitivedysfunction in patients with cerebral microbleedson T2 -weighted gradient-echo MRI[J]. Brain, 2004,127:2265-2275.17 van Es AC, van der Grond J, de Craen AJ, et al.Cerebral microbleeds and cognitive functioning in thePROSPER study[J]. Neurology, 2011, 77:1446-1452.18 van Norden AG, van Uden IW, de Laat KF, etal. Cerebral microbleeds are related to subjectivecognitive failures:the RUN DMC study[J]. NeurobiolAging, 2013, 34:2225-2230.19 范慧敏, 张微微, 黄勇华, 等. 缺血性脑血管病患者脑微出血的危险因素及其对认知功能的影响[J]. 中国脑血管病杂志, 2011, 8:125-129.20 Zhang M, Chen M, Wang Q, et al. Relationshipbetween cerebral microbleeds and cognitive functionin lacunar infarct[J]. J Int Med Res, 2013, 41:347-355.21 G r e g o i r e SM, Smi t h K , J ä g e r H R , e t a l .Cerebral microbleeds and long-term cognitiveoutcome:longitudinal cohort study of stroke clinicpatients[J]. Cerebralvasc Dis, 2012, 33:430-435.22 Ayaz M, Boikov AS, Haacke EM, et al. Imagingcerebral microbleeds using susceptibility weightedimagi ng:One st ep towa rd det e ct i ng va scula rdementia[J]. J Magn Reson Imaging, 2010, 31:142-148.23 Werring DJ, Gregoire SM, Cipolotti L. Cerebralmicrobleeds and vascular cognitive impairment[J]. JNeurol Sci, 2010, 299:131-135.24 Van der Flier WM, Cordonnier C. Microbleeds invascular dementia:clinical aspects[J]. Exp Gerontol,2012, 47:853-857.25 Liem MK, Lesnik Oberstein SA, Haan J, et al. MRIcorrelates of cognitive decline in CADASIL:a 7-yearfollow-up study[J]. Neurology, 2009, 72:143-148.26 Pettersen JA, Sathiyamoorthy G, Gao FQ, et al.Microbleed topography, leukoaraiosis, and cognitionin probable Alzheimer disease from the Sunnybrookdementia study[J]. Arch Neurol, 2008, 65:790-795.27 Cordonnier C, van der Flier WM. Brain microbleedsand Alzheimer's disease:innocent observation or keyplayer?[J]. Brain, 2011, 134:335-344.28 Goos JD, Kester MI, Barkhof F, et al. Patients withAlzheimer disease with multiple microbleeds:relationwith cerebrospinal fluid biomarkers and cognition[J].Stroke, 2009, 40:3455-3460.29 Staekenborg SS, Koedam EL, Henneman WJ, etal. Progression of mild cognitive impairment todementia:contribution of cerebrovascular diseasecompared with medial temporal lobe atrophy[J].Stroke, 2009, 40:1269-1274.30 De Reuck JL. The significance of small cerebralbleeds in neurodegenerative dementia syndromes[J].Aging Dis, 2012, 3:307-312.31 Nardone R, De Blasi P, Seidl M, et al. Cognitivefunction and cholinergic transmission in patients withsubcortical vascular dementia and microbleeds:a TMSstudy[J]. J Neural Transm, 2011, 118:1349-1358.32 Charidimou A, Werring DJ. Cerebral microbleeds andcognition in cerebrovascular disease:An update[J]. JNeurol Sci, 2012, 322:50-55.33 Vi s w a n a t h a n A1 , C h a b r i a t H . C e r e b r a lmicrhemorrhage[J]. Stroke, 2006, 37:550-555.34 Kalaria RN, Ballard C. Overlap between pathologyof Alzheimer disease and vascular dementia[J].Alzheimer Dis Assoc Disord, 1999, 13:S115-S123.35 Jellinger KA. Alzheimer disease and cerebrovascularpathology:an update[J]. J NeuralTransm, 2002,109:813-836.36 Dierksen GA, Skehan ME, Khan MA, et al. Spatialrelation between microbleeds and amyloid deposits inamyloid angiopathy[J]. Ann Neurol, 2010, 68:545-548.37 C h a r i d i m o u A , We r r i n g D J . C e r e b r a lmicrobleeds:detection, mechanisms and clinicalchallenges[J]. Future Neurol, 2011, 6:587-611. |