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表1 静脉溶栓预后预测模型及预测能力比较

模型名称发表年限样本量（例数）

预测C值

（内部验证）

预测C值a

（欧洲多中心验证）

预测C值a

（中国台湾验证）

预测C值（IST-3验证）

SICH 预后不良

S-TPI 2006 2184 0.79/0.78 - - 0.64 0.80

MSS 2008 1205 0.69 0.63 0.62 - -

HAT 2008 400 0.72 0.65 0.69 0.62 0.71

iScore 2012 12 686 0.67 - - - -

GRASPS 2012 10 242 0.71 0.67 0.61 0.63 0.77

SEDAN 2012 974 0.77 0.70 - 0.62 0.74

DRAGON 2012 1319 0.84 - - 0.65 0.78

SITS 2012 31 627 0.70 0.64 0.61 0.63 0.66

SPAN-100 2013 624 0.68/0.64 0.56 0.55 0.56 0.66

THRIVE 2013 5724 0.76 - - 0.60 0.76

IST-3 2014 1515 0.68 - - 0.68 0.71

注：S-TPI：卒中溶栓预测模型；MSS：多中心卒中调查预测模型；HAT：溶栓后出血模型；iScore模型：加拿大急性缺血性卒中死亡风险模型；SITS模型：静脉

溶栓实施安全监测研究模型；SPAN-100模型：使用年龄和NIHSS评分的卒中预后预测模型；THRIVE模型：血管事件健康风险汇总评分；IST-3模型：国际卒

中研究模型；GRASPS：基线血糖水平、种族、年龄、性别、基线收缩压、基线NIHSS量表；SEDAN：基线血糖水平、入院CT早期梗死征象、脑动脉高密度征、年

龄、基线NIHSS量表；DRAGON：入院头部CT脑动脉高密度影或早期梗死征象、卒中前mRS＞1、年龄、基线血糖水平、发病到治疗时间、基线NIHSS量表。a ：欧

洲多中心队列验证及中国台湾队列验证中仅列出ECASS-Ⅱ标准下的预测C 值

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