1 Marsh JD, Keyrouz SG. Stroke prevention andtreatment[J]. J Am Coll Cardiol, 2010, 56:683-691.2 Stemer A, Lyden P. Evolution of the thrombolytictreatment window for acute ischemic stroke[J]. CurrNeurol Neurosci Rep, 2010, 10:29-33.3 Go AS, Mozaffarian D, Roger VL, et al. Heart diseaseand stroke statistics--2014 update:a report from theAmerican Heart Association[J]. Circulation, 2014,129:e28-e292.4 Adeoye O, Hornung R, Khatri P, et al. Recombinanttissue-type plasminogen activator use for ischemicstroke in the United States:a doubling of treatmentrates over the course of 5 years[J]. Stroke, 2011,42:1952-1955.5 Wen YD, Sheng R, Zhang LS, et al. Neuronal injuryin rat model of permanent focal cerebral ischemiais associated with activation of autophagic andlysosomal pathways[J]. Autophagy, 2008, 4:762-769.6 Carloni S, Buonocore G, Balduini W. Protective roleof autophagy in neonatal hypoxia-ischemia inducedbrain injury[J]. Neurobiol Dis, 2008, 32:329-339.7 Koike M, Shibata M, Tadakoshi M, et al. Inhibition ofautophagy prevents hippocampal pyramidal neurondeath after hypoxic-ischemic injury[J]. Am J Pathol,2008, 172:454-469.8 Kuma A, Hatano M, Matsui M, et al. The role ofautophagy during the early neonatal starvationperiod[J]. Nature, 2004, 432:1032-1036.9 Mizushima N, Klionsky DJ. Protein turnover viaautophagy:implications for metabolism[J]. Annu RevNutr, 2007, 27:19-40.10 Kl io n s k y DJ. T h e mol e c u l a r ma c h i n e r y ofautophagy:unanswered questions[J]. J Cell Sci, 2005,118:7-18.11 Massey AC, Zhang C, Cuervo AM. Chaperonemediatedautophagy in aging and disease[J]. Curr TopDev Biol, 2006, 73:205-235.12 Mi z u sh ima N, Lev i ne B, Cue r vo AM, e t a l.Autophagy f ights disease through cellular selfdigestion[J]. Nature, 2008, 451:1069-1075.13 Zhu C, Wang X, Xu F, et al. The influence of age onapoptotic and other mechanisms of cell death aftercerebral hypoxia-ischemia[J]. Cell Death Differ, 2005,12:162-176.14 Xi a DY, Li W, Qi a n HR , e t a l . I s c h emi apreconditioning is neuroprotective in a rat cerebralischemic injury model through autophagy activationand apoptosis inhibition[J]. Brazi J Med Biol Res,2013, 46:580-588.15 Yan W, Zhang H, Bai X, et al. Autophagy activationis involved in neuroprotection induced by hyperbaricoxygen preconditioning against focal cerebralischemia in rats[J]. Brain Res, 2011, 1402:109-121.16 Yang Y, Gao K, Hu Z, et al. Autophagy upregulationand apoptosis downregulation in DAHP and triptolidetreated cerebral ischemia[J]. Mediators Inflamm, 2015,2015:120198.17 Gao L, Jiang T, Guo J, et al. Inhibition of autophagycontributes to ischemic postconditioning-inducedneuroprotection against focal cerebral ischemia inrats[J]. PLoS one, 2012, 7:e46092.18 Puyal J, Vaslin A, Mottier V, et al. Postischemictreatment of neonatal cerebral ischemia should targetautophagy[J]. Ann Neurol, 2009, 66:378-389.19 Zheng YQ, Liu JX, Li XZ, et al. RNA interferencemediateddownregulation of Beclin1 attenuatescerebral ischemic injury in rats[J]. Acta PharmacolSin, 2009, 30:919-927.20 Yang Z, Zhong L, Zhong S, et al. Hypoxia inducesmicroglia autophagy and neural inflammation injuryin focal cerebral ischemia model[J]. Exp Mole Pathol,2015, 98:219-224.21 Wu Z, Zou Z, Zou R, et al. Electroacupuncturepretreatment induces tolerance against cerebralischemia/reperfusion injury through inhibition of theautophagy pathway[J]. Mol Med Rep, 2015, 11:4438-4446.22 Chong ZZ, Shang YC, Wang S, et al. A critical kinasecascade in neurological disorders:PI3K, Akt, andmTOR[J]. Future Neurol, 2012, 7:733-748.23 Glick D, Barth S, Macleod KF. Autophagy:cellularand molecular mechanisms[J]. J Pathol, 2010, 221:3-12.24 Xingyong C, Xicui S, Huanxing S, et al. Upregulationof myeloid cell leukemia-1 potentially modulatesbeclin-1-dependent autophagy in ischemic stroke inrats[J]. BMC Neurosci, 2013, 14:56.25 Xu F, Li J, Ni W, et al. Peroxisome proliferatoractivatedreceptor-gamma agonist 15d-prostaglandinJ2 mediates neuronal autophagy after cerebralischemia-reperfusion injury[J]. PLoS One, 2013,8:e55080.26 Qi Z, Dong W, Shi W, et al. Bcl-2 phosphorylationtriggers autophagy switch and reduces mitochondrialdamage in limb remote ischemic conditioned rats afterischemic stroke[J]. Transl Stroke Res, 2015, Mar 7.[Epub ahead of print].27 Poels J, Spasic MR, Callaerts P, et al. Expanding rolesfor AMP-activated protein kinase in neuronal survivaland autophagy[J]. Bioessays, 2009, 31:944-952.28 Li J, McCullough LD. Effects of AMP-activated protein kinase in cerebral ischemia[J]. J Cereb BloodFlow Metab, 2010, 30:480-492.29 Chen AC, Arany PR, Huang YY, et al. Low-level lasertherapy activates NF-κB via generation of reactiveoxygen species in mouse embryonic fibroblasts[J].PLoS One, 2011, 6:e22453.30 Li WL, Yu SP, Chen D, et al. The regulatory role ofNF-kappaB in autophagy-like cell death after focalcerebral ischemia in mice[J]. Neuroscience, 2013,244:16-30.31 Cui DR, Wang L, Jiang W, et al. Propofol preventscerebral ischemia-triggered autophagy activation andcell death in the rat hippocampus through the NFkappaB/p53 signaling pathway[J]. Neuroscience, 2013,246:117-132.32 Wang PR, Wang JS, Zhang C, et al. Huang-Lian-Jie-Du-Decotion induced protective autophagy against theinjury of cerebral ischemia/reperfusion via MAPKmTORsignaling pathway[J]. J Ethnopharmacol, 2013,149:270-280.33 Althaus J, Bernaudin M, Petit E, et al. Expression ofthe gene encoding the pro-apoptotic BNIP3 proteinand stimulation of hypoxia-inducible factor-1alpha(HIF-1alpha) protein following focal cerebral ischemiain rats[J]. Neurochem Int, 2006, 48:687-695.34 Xin XY, Pan J, Wang XQ, et al. 2-methoxyestradiolat t enuat e s autophag y a ct ivat ion af t e r globalischemia[J]. Can J Neurol Sci, 2011, 38:631-638.35 Cho B, Choi SY, Park OH, et al. Differentialexpression of BNIP family members of BH3-onlyproteins during the development and after axotomy inthe rat[J]. Mol Cells, 2012, 33:605-610.36 Zhang J, Ney PA. Mechanisms and biology of B-cellleukemia/lymphoma 2/adenovirus E1B interactingprotein 3 and Nip-like protein X[J]. Antioxid RedoxSignal, 2011, 14:1959-1969.37 Kubota C, Torii S, Hou N, et al. Constitutive reactiveoxygen species generation from autophagosome/lysosome in neuronal oxidative toxicity[J]. J BiolChem, 2010, 285:667-674.38 Mehta SL, Kumari S, Mendelev N, et al. Seleniumpreser ves mitochondr ial f unct ion, st imulatesmitochondrial biogenesis, and reduces infarct volumeafter focal cerebral ischemia[J]. BMC Neurosci, 2012,13:79.39 Puyal J, Ginet V, Grishchuk Y, et al. Neuronalautophagy as a mediator of life and death:contrastingroles in chronic neurodegenerative and acute neuraldisorders[J]. Neuroscientist, 2012, 18:224-236.40 Kulbe JR, Mulcahy Levy JM, Coultrap SJ, et al.Excitotoxic glutamate insults block autophagic flux inhippocampal neurons[J]. Brain Res, 2014, 1542:12-19.41 Ouyang YB, Giffard R. ER-mitochondria crosstalkduring cerebral ischemia:molecular Chaperones andER-mitochondrial calcium transfer[J]. Int J Cell Biol,2012, 2012:493934. |