关键词: 脑梗死; 颈动脉斑块; 同型半胱氨酸; 多普勒超声

Abstract:

Objective To explore the relationship between serum homocysteine and carotid atherosclerosis plaque in Chinese acute cerebral infarction patients. Methods All 196 hospitalized patients with acute cerebral infarction from June 2013 to June 2014, coming from Chaoyang Hospital west campus, were retrospectively analyzed. All patients were received carotid ultrasonography screening. To all patients, maximal thickness of carotid atherosclerosis plaque (MTCAP) and serum homocysteine (HCY) were assessed. Patients were classified into two groups according to the presence or absence of plaque (152 cases and 44 cases, respectively). Results The median of HCY in none plaque group (n=44) and plaque group (n=152) is 11.6 μmol/L and 14.0 μmol/L, respectively, with P value 0.011 (<0.05) in Rank test. Spearman correlation test showed that there was a liner relationship between HCY and MTCAP, r =0.247, P =0.0001 (<0.05). Logistic regression revealed that age (odds ratio [OR] value 1.089, 95%confidence interval [CI] 1.050~1.131, P =0.0001), male (OR value 4.304, 95%CI 1.738~10.660, P =0.002), hypertension history (OR value 3.864, 95%CI 1.750~8.534, P =0.001) were independent risk factors of carotid atherosclerosis plaque, but HCY (OR value 1.026, 95%CI 0.973~1.081, P =0.344) was not. However, the analysis of none cardiac cerebral infarction subgroup (n =183) according to TOAST classification method shows that HCY is an independent risk factor of carotid atherosclerosis plaque (OR value 1.267, 95%CI 1.006~1.430, P =0.003). Conclusion For Chinese acute infarction patients, serum HCY positively correlates to maximal thickness of atherosclerosis plaque. And HCY is an independent risk factor to the presence of carotid atherosclerosis plaque in none cardiac cerebral infarction patients.

Key words: Cerebral infarction; Carotid atherosclerosis plaque; Homocysteine; Ultrasonography