1 Jeyaseelan K, Lim KY, Armugam A. Neuroprotectantsin stroke therapy[J]. Expert Opin Pharmacother, 2008,9:887-900.2 Tuttolomondo A, Di Sciacca R, Di Raimondo D, etal. Neuron protection as a therapeutic target in acuteischemic stroke[J]. Curr Top Med Chem, 2009, 9:1317-1334.3 Hazell AS. Excitotoxic mechanisms in stroke:anupdate of concepts and treatment strategies[J].Neurochem Int, 2007, 50:941-953. 4 Bano D, Nicotera P. Ca2+ signals and neuronal death inbrain ischemia[J]. Stroke, 2007, 38:674-676.5 Allen CL, Bayraktutan U. Oxidative stress and its rolein the pathogenesis of ischaemic stroke[J]. Int J Stroke,2009, 4:461-470.6 Grotta J. Lubeluzole treatment of acute ischemicstroke. The US and Canadian Lubeluzole IschemicStroke Study Group[J]. Stroke, 1997, 28:2338-2346.7 Dyker AG, Lees KR. Duration of neuroprotectivetreatmemt for ischemic stroke[J]. Stroke, 1998,29:535-542.8 Zivin JA. Factors determining therapeutic window forstroke[J]. Neurology, 1998, 50:599-603.9 Thompson CB. Apoptosis in the pathogenesis andtreatment of disease[J]. Science, 1995, 267:1456-1462.10 Jacobson MD, Raff MC. Programmed cell death andBcl-2 protection in very low oxygen[J]. Nature, 1995,374:814-816.11 Shao W, Zhang SZ, Tang M, et al. Suppressionof neuroinf lammation by astrocytic dopamine D2receptors via αB-crystallin[J]. Nature, 2013, 494:90-94.12 Zhao Y, Rempe DA. Targeting astrocytes for stroketherapy[J]. Neurotherapeutics, 2010, 7:439-451.13 Li Y, Liu Z, Xin H, et al. The role of astrocytes inmediating exogenous cell-based restorative therapyfor stroke[J]. Glia, 2014, 62:1-16.14 Hines DJ, Haydon PG. Inhibition of a SNAREsensitivepathway in astrocytes attenuates damagefollowing stroke[J]. J Neurosci, 2013, 33:4234-4240.15 Jiang P, Chen C, Wang R, et al. hESC-derived Olig2+progenitors generate a subtype of astroglia withprotective effects against ischaemic brain injury[J].Nat Commun, 2013, 4:2196.16 Rajendran P, Rengarajan T, Thangavel J, et al. Thevascular endothelium and human diseases[J]. Int J Bio Sci, 2013, 9:1057-1069.17 Zhao YH, Yuan B, Chen J, et al. Endothelialprogenitor cells:therapeutic perspective for ischemicstroke[J]. CNS Neurosci Ther, 2013, 19:67-75.18 Shah K, Abbruscato T. The role of blood-brain barriertransporters in pathophysiology and pharmacotherapyof stroke[J]. Curr Pharm Des, 2014, 20:1510-1522.19 Nor abe rg J, Poul sen FR, Bla abje rg M, et a l.Organotypic hippocampal slice cultures for studiesof brain damage, neuroprotection and neurorepair[J].Curr Drug Targets CNS Neurol Disord, 2005, 4:435-452.20 Lo EH, Dalkara T, Moskowitz MA. Mechanisms,challenges and opportunities in stroke[J]. Nat RevNeurosci, 2003, 4:399-414.21 Pacifici M, Peruzzi F. Isolation and culture of ratembryonic neural cells:a quick protocol[J]. J Vis Exp,2012, 24:e3965.22 McCarthy KD, de Vellis J. Preparation of separateastroglial and oligodendroglial cell cultures from ratcerebral tissue[J]. J Cell Biol, 1980, 85:890-902.23 Chen Z, Rubin J, Tzima E. Role of PECAM-1 inar teriogenesis and specif ication of preexistingcollaterals[J]. Circ Res, 2010, 107:1355-1363.24 Sajja RK, Prasad S, Cucullo L. Impact of alteredglycaemia on blood-brain barrier endothelium:an invitro study using the hCME/D3 cell line[J]. FluidsBarriers CNS, 2014, 11:8.25 Adamchik Y, Frantseva MV, Weisspapir M, et al.Methods to induce primary and secondary traumaticdamage in organotypic hippocampal slice cultures[J].Brain Res Brain Res Protoc, 2000, 5:153-158.26 Xue Q, Liu Y, Qi H, et al. A novel brain neurovascularunit model with neurons, astrocytes and microvascularendothelial cells of rat[J]. Int J Bio Sci, 2013, 9:174-189. |