1 Wa ng YL，Liao XL，Zhao XQ，et a l. Using

recombinant tissue plasminogen activator to treat

acute ischemic stroke in China：analysis of the results

from the Chinese National Stroke Registry (CNSR)[J].

Stroke，2011，42：1658-1664.

2 Roger VL，Go AS，Lloyd-Jones DM，et al. Heart

disease and stroke statistics—2011 update：a report

from the American Heart Association[J]. Circulation，

2011，123：e18-e209.

3 Bonetti PO，Lerman LO，Lerman A. Endothelial

dysfunction：a marker of atherosclerotic risk[J].Arterioscler，Thromb，Vasc Biol，2003，23：168-175.

4 Bonet t i PO，Pumper GM，Higano ST，e t a l .

Noninvasive identification of patients with early

coronary atherosclerosis by assessment of digital

reactive hyperemia[J]. J Am Coll Cardiol，2004，44：

2137-2141.

5 Thijssen DH，Black MA，Pyke KE，et al. Assessment

of flow-mediated dilation in humans：a methodological

and physiological guideline[J]. Am J Physiol Heart

Circ Physiol，2011，300：H2-12.

6 高宇，王建华，黄晓玲，等. 超声对短期胰岛素泵治疗

改善2 型糖尿病血管功能的临床观察[J]. 中国超声医

学杂志，2011，27：920-922.

7 European Stroke Initiative Executive Committee，

EUSI Writing Committee，Olsen TS，et al. European

Stroke Init iative recommendat ions for st roke

management-update 2003[J]. Cerebrovasc Dis，2003，

16：311-337.

8 中华医学会糖尿病学分会. 中国2型糖尿病防治指南

（2013年版）[J]. 中华糖尿病杂志，2014，6：447-498.

9 Keevil JG，Cullen MW，Gangnon R，et al. Implications

of cardiac risk and low-density lipoprotein cholesterol

distributions in the United States for the diagnosis and

treatment of dyslipidemia：data from National Health

and Nutrition Examination Survey 1999 to 2002[J].

Circulation，2007，115：1363-1370.

10 Becker RC，Meade TW，Berger PB，et al. The

primary and secondary prevention of coronary artery

disease：American College of Chest Physicians

Evidence-Based Clinical Practice Guidelines (8th

Edition)[J]. Chest，2008，133(6 Suppl)：776S-814S.

11 Cor ret t i MC，Anderson TJ，Benjamin EJ，e t

al. Guidelines for the ultrasound assessment of

endothelial dependent f low mediated vosodilation

of the brachial artery：a report of the International

Brachial Artery Reactivity Task Force[J]. J Am Coll

Cardiol，2002，39：2572265.

12 Celermajer DS，SorensenKE，Gooch VM，et al.

Non-invasive detection of endothelial dysfuntion

in children and adults at risk of atherosclerosis[J].

Lancet，1992，340(8828)：1111-1115.

13 中华医学会神经科分会. 各类脑血管病诊断要点[J].

中华神经科杂志，1996，29：379-380.

14 Worthmann H，Chen S，Martens-Lobenhoffer J，et al.

High plasma dimethylarginine levels are associated

with adverse clinical outcome after stroke[J]. J

Atheroscler Thromb，2011，18：753-761.

15 Vita JA，Treasure GB，Nabel EG，et al. Coronary

vasomotor response to actylcholine relates to risk

factors for coronary artery disease[J]. Cirulation，

1990，81：491-497.16 Goff DC Jr，Lloyd-Jones DM，Bennett G，et al.

2013 ACC/AHA guideline on the assessment of

cardiovascular risk：A report of the American College

of Cardiology/American Heart Association task force

on practice guidelines[J]. Circulation，2014，129(25

Suppl 2)：S49-73.

17 Joannides R，Haefeli WE，Linder L，et al. Nitric

oxide is responsible for f low-dependent dilatation

of human peripheral conduit arteries in vivo[J].

Circulation，1995，91：1314-1319.

18 Lieberman EH，Gerhard MD，Uehata A，et al.

Flow-induced vasodilation of the human brachial

artery is impaired in patients <40 years of age with

coronary artery disease[J]. Am J Cardiol，1996，78：

1210-1214.

19 Joannides R，Richard V，Haefeli WE，et al. Role

of basal and stimulated release of nitric oxide in

the regulation of radial artery caliber in humans[J].

Hypertension，1995，26：327-331.

20 吴康智，尚虎虎，章银环，等. 颈动脉粥样硬化、血管

内皮功能与冠心病的相关性研究[J]. 武警医学院学

报，2010，19：783-785.

20 Nilsson PM，Boutouyrie P，Cunha P，et al. Early

vascular ageing in translation：from laboratory

investigations to clinical applications in cardiovascular

prevention[J]. J Hypertens，2013，31：1517-1526.

21 陈旭东. 彩色高频超声探查肱动脉内皮舒张功能与冠

心病患者颈动脉内-中膜厚度的临床意义[J]. 中国实用

医药，2012，7：65-66.

22 Mai XL，Teng GJ. Characteristic of endothelial

progenitor cell and it's roles in the diseases of

atheroselerosis[J]. Zhonghua Xinxueguanbing Zazhi，

2007，35(8)：775-777.

23 van Bussel FCG. A control systems approach toquantify wall shear stress normalization by f lowmediated

dilation in the brachial artery[J]. PLoS One，

2015，10：e0115977.

24 Bruno RM，Ghiadoni L. Vascular smooth muscle

function：defining the diabetic vascular phenotype[J].

Diabetologia，2013，56：2107-2109.

25 Flammer AJ，Anderson T，Celermajer DS，et al. The

assessment of endothelial function：from research into

clinical practice[J]. Circulation，2012，126：753-767.

26 Peng Q，Huang Y，Sun W，et al. Association among

cerebral microbleeds，cerebral large-artery disease

and endothelial dysfunction[J]. Chin Med J(Engl)，

2014，127：3204-3208.

27 Santos-Ga rcía D1，Blanco M，Serena J，et al.

Impaired brachial f low-mediated dilation is a

predictor of a new-onset vascular event after stroke[J].

Cerebrovasc Dis，2011，32：155-162.

28 肖艳，张晓莺. 缺血性脑卒中复发的危险因素分析[J].

实用医院临床杂志，2010，7：49-51.

29 陈明，胡申江，张健，等. 不同危险度的高血压病人血

管内皮功能[J]. 高血压杂志，2006，14：257-260.

30 Yav uz D，Koc M，Toprak A，et al. Ef fects of

ACE inhibition and AT1 receptor antagonism on

endothelial function and insulin sensitivity in

essential hypertensive patients[J]. J Renin Angiotens

in Aldosterone System，2003，4：197-203.

31 Anderson JL，Carlquist JF，Muhlestein JB，et al.

Evaluation of C-reactive protein，an inflammation

maker，and infectious serology as risk factors for

coronary artery disease and myocardial infarction[J].

J Am Coll Cardiol，1998，32：35-41.

32 Herman AG，Moncada S. Therapeutic potential of

nitric oxide donors in the prevention and treatment of

atherosclerosis[J]. Eur Heart J，2005，26:1945-1955.