关键词: 脑淀粉样血管病; 自发性脑出血; 低密度脂蛋白受体相关蛋白1; 晚期糖基化终产物受体

Abstract:

Objective To retrospectively analyze the prevalence of cerebral amyloid angiopathy (CAA) in the patients with spontaneous intracerebral hemorrhage (ICH) who received surgical treatment, and related the immune vascular factor co-expressions as to explore the possible immunological vascular damage of CAA-ICH. Methods Surgical samples of 46 ICH patients from 2010 to 2011 were enrolled, including 27 male patients and 19 female patients. The average age was 56±15 years old. The co-expression of amyloid β (Aβ), glycosylation end products (RAGE) and low-density lipoprotein receptor related protein-1 (LRP1) protein in the samples was detected by immunofluorescence and immunohistochemistry. Results Among 46 cases of ICH patients, 8 patients (17.39%, 5 males and 3 females) were diagnosed with CAA by pathology. The co-expression (positive rate 100%) of Aβ, LRP1 and RAGE proteins were detected in the patients with CAA, while others patients did not show co expression of Aβ, LRP1 and RAGE proteins. Compared with that in others patients, the level of LRP1 expression was significantly lower in the patients with CAA (P =0.031), while the level of RAGE expression was significantly higher (P =0.015). Conclusion CAA is one of the key reasons leading to the disease of ICH. The abnormal expression of RAGE and LRP1may play a vital role in the pathogenesis of CAA associated ICH.

Key words: Cerebral amyloid angiopathy; Spontaneous intracerebral hemorrhage; Low-density lipoprotein receptor related protein-1; Receptor for advanced glycation end products