中国卒中杂志 ›› 2016, Vol. 11 ›› Issue (08): 704-708.

• 综述 • 上一篇    下一篇

脑梗死后VEGF及bFGF对神经干细胞增殖分化的机制研究进展

杨炎歌,段淑荣   

  1. 150001 哈尔滨哈尔滨医科大学附属第一医院神经内科
  • 收稿日期:2016-03-28 出版日期:2016-08-20 发布日期:2016-08-20
  • 通讯作者: 段淑荣 duanshurongsj@163.com
  • 基金资助:

    黑龙江省自然科学基金项目(ZD201418)

New Progress in the Study of the Mechanism of bFGF and VEGF on Proliferation and Differentiation of Neural Stem Cells after Cerebral Infarction

  • Received:2016-03-28 Online:2016-08-20 Published:2016-08-20

摘要:

缺血性卒中因其发病机制复杂,迄今为止,仍未发现确切有效治疗方法。随着研究深入, 神经干细胞(neural stem cells,NSCs)作为新的研究靶点,为卒中的治疗提供了新的前景。目前脑梗 死后促进内源神经干细胞增殖分化的影响因素众多,但有研究表明碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)及血管内皮生长因子(vascular endothelial growth factor,VEGF)对NSCs 的增殖及分化起到了不容忽视的作用。通过研究VEGF和bFGF在脑缺血后NSCs增殖分化中的作用机 制,为临床脑缺血的靶向治疗提供理论基础。

文章导读: 介绍VEGF及bFGF对神经干细胞增殖、分化的可能机制,为未来研究提供方向。

关键词: 缺血性卒中; 神经干细胞; 增殖; 分化; 碱性成纤维细胞生长因子; 血管内皮生长因子

Abstract:

Because the pathogenesis of ischemic stroke is complex, so far, there are still no effective treatments. With deeper study, neural stem cells (NSCs) is taken as a new target that provides a new broad prospect for stroke. To this day, there are studies finding that proliferation and differentiation of NSCs was mediated by many environmental factors after cerebral arterial thrombosis, among which, vascular endothelial growth factor (bFGF) and VEGF plays important roles in the proliferation and differentiation. It provides a theoretical therapy of clinical cerebral ischemia via studying the mechanism of bFGF and vascular endothelial growth factor (VEGF) on the proliferation and differentiation of NSCs after cerebral infarction.

Key words: Ischemic stroke; Neural stem cells; Proliferation; Differentiation; Basic fibroblast
growth factor;
Vascular endothelial growth factor