中国卒中杂志 ›› 2013, Vol. 8 ›› Issue (09): 768-772.

• 综述 • 上一篇    下一篇

卒中神经保护研究:过去,现状与未来

刘勇,冯国栋,张光运,韩军良,赵钢   

  1. 710032 西安
    第四军医大学西京医院神经内科
  • 收稿日期:2013-06-03 出版日期:2013-09-20 发布日期:2013-09-20
  • 通讯作者: 赵钢 zhaogang@fmmu.edu.com
  • 基金资助:

    国家“重大新药创制”科技重大专项
    (2008ZX09lO1.026)
    陕西省社发攻关基金
    (省2012K15-02-06)

Research on Neuroprotective Strategy of Stroke: The Past, Present and Future

  1. Department of Neurology, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, China
  • Received:2013-06-03 Online:2013-09-20 Published:2013-09-20

摘要:

目前正在进行的卒中神经保护策略研究主要有白蛋白、镁和低温治疗等;一些有前景的神经保护剂如人参皂苷Rd(ginsenoside Rd,GSRd)、突触后膜密95蛋白阻断剂NA-1(a 20-amino acid peptide,Tat-NR2B9c)等的研究还在探索中。神经保护研究的30年经历了由高潮到低谷再到新高潮的发展阶段,而未来神经保护治疗的研究要取得更好的发展需注重:动物实验中的严格设计,研究对象应从龋齿动物向灵长类动物转化,评价方法由行为评估向影像学评估转变;而整体研究范式应扩展到血管神经网络。

文章导读: 概述卒中神经保护研究现状,未来研究趋势应基于增加动物实验与临床试验的同质性及血管神经网络研究范式两个视角。

关键词: 卒中; 神经保护策略; 人参皂苷Rd

Abstract:

Many ongoing studies of neuroprotective strategy of stroke include albumin, magnesium and cryotherapy therapy. There are also a number of promising neuroprotectants in preclinical development including ginsenoside Rd, NA-1 (Tat-NR2B9c), an inhibitor of postsynaptic density-95 protein etc. Thirty years' study of neuroprotective strategy of stroke experiences the development process from the peak to the trough then to new climax. However, to achieve better development, future research should focus on:conduct a strict design; the object of study should converse from dental caries animal to primate; the evaluation method should converse from behavioral assessment to radiographic evaluation; research paradigm should extend to vascular neural network.

Key words: Stroke; Neuroprotective strategy; Ginsenoside Rd