关键词: 超声检查; 介入性; 血管造影术; 颈动脉疾病; 颈动脉狭窄; 新生血管; 病理性; 脑梗死

Abstract: Objective To quantitatively assess the neovascularization within human carotid atheroscleroticplaque in patients with ischemic stroke by real-time contrast-enhanced ultrasonography.Methods Ninety-six patients with carotid atherosclerotic plaques were examined with real-timecontrast-enhanced ultrasonography and divided into two groups: Stroke group including sixtyeightpaitents with ischemic stroke and non-stroke group including twenty-eight patients withoutischemic stroke. Carotid atherosclerotic plaques were detected using the real-time contrastenhancedultrasonography and analyzed using coded phase-inversion harmonic ultrasound(CPI)technology analysis software. The results of the two groups were compared.Results The enhanced rate and enchanced intensity of stroke group was significantly higher thanthat of non-stroke group(P <0.05). The arrival time(AT) and the time to peak(TTP) have significantlydifference in different position of the same group(P <0.05), and did not have significantly differencein the same position of different group(P >0.05).Conclusion The real-time contrast-enhanced ultrasonography can assess the neovascularizationwithin carotid atherosclerotic plaque non-invasively and quantitatively, and provide valuableinformation for plaque risk stratification. The density of intraplaque nevascularization in carotidarteries on ischemic stroke is higher than that of the control group.

Key words: Ultrasonography; interventional; Aotrography; Carotid artery diseases; Carotid stenosis; Neovascularization; pathologic; Brain infarction