关键词: 帕金森病; 半胱氨酸; 叶酸; 脑梗死

Abstract: Objective To conduct a comparsion study on the change of plasma homocystein (Hcy) in patientswith Parkinson’s disease (PD) and cerebral infarction , and to explore its clinical significance.Methods We examined the levels of plasma Hcy, folic acid and vitamin B12 of patients among PD,cerebral infarction and control group. The levels of plasma Hcy, folic acid and vitamin B12 of PDpatients were analyzed. The relationships among Hcy level and PD severity, PD duration, clinicaltypes, mood status, cognitive function and Madopar treatment were analyzed.Results 1 Hcy levels in patients with PD, cerebral infarction and control group were 20±11μmol/L, 16±7 μmol/L and 11±3 μmol/L, respectively. Hcy levels in patients with PD and cerebralinfarction were all significantly higher than that of control group (P <0.05 or P <0.01, respectively).Hcy level in PD patients was significantly higher than that of patients with cerebral infarction(P <0.01); 2 The levels of plasma folic acid and vitamin B12 in PD patients were 6±5 μg/L and 514±345ng/L; it was negatively correlated (r =-0.453, P <0.01) between the level of Hcy and folic acid inPD patients; and there was no significant correlation between Hcy level and the level of vitaminB12 (r =-0.268, P >0.05); 3 Hcy levels in PD patients with mild, moderate and severe degreesevaluated by Hoehn-Yahr staging were significantly different (16±8 μmol/L, 21±9 μmol/L and35±3 μmol/L, respectively, P <0.05); 4 There were no relationships among Hcy level and PDduration, clinical types, mood status, cognitive function and Madopar treatment.Conclusion Hcy level in PD patients was significantly elevated, which was closely correlatedwith disease severity. Hcy level and folic acid level was negatively correlated.

Key words: Parkinson's disease; Cysteine; Folic acid; Brain infarction