关键词: 认知障碍; 认知筛查量表; 脑梗死; 痴呆; 血管性

Abstract: Objective To develop a screening battery for mild vascular cognitive impairment (mVCI).Methods Eighty mVCI patients (mVCI with subcortical small vessel disease, mVCI-SSVD, n = 56; mVCI with multi-infarct or strategic infarct, mVCI-MI/SI, n=24) and 80 normal control subjects were evaluated with cognitive measures tapping executive function and mental processing speed. Tests with fair discriminating validity were selected to form a screening battery. The sensitivity and specificity of the battery in detecting mVCI and its subtypes were determined.Results mVCI and its subtype groups were all impaired in executive function and mental processing speed. Four individual tests were chosen for the screening battery. The battery achieved good sensitivity (80.0%-85.7%) and specificity (88.8%-96.3%) in differentiating mVCI, mVCI-SSVD, and mVCI-MI/SI patients from normal controls. Similarly high validity was obtained in discriminating mVCI, mVCI-SSVD versus controls with MMSE scores of 28 or above.Conclusion The screening battery shows good discrimination in detecting mVCI and its subgroups from normal controls although further confirm is essential through more cases.

Key words: Cognition disorders; Cognitive screening battery; Brain infarction; Dementia; vascular