关键词: 痴呆; 血管性; 胆碱酯酶抑制剂; 美金刚; 尼莫地平; 尼麦角林

Abstract: 【Abstract】 Vascular dementia is a kind of cognitive dysfunction clinical syndrome causedby cerebrovascular diseases. Relevant drug therapy includes anticholinesterase, N-aspartic acidmethyl-D-receptor inhibitors, Nimodipine, statins and nicergoline etc. The effect of donepezil iscontroversy; galanthamine is effective to the dementia caused by both Alzheimer disease (AD) andcerebrovascular diseases; rivastigmine in vascular dementia those who are old and may have ADhas the obvious effect in cognitive; memantine in mild to moderate vascular dementia has goodcurative effect and tolerability; most tests show nimodipine in vascular cognitive dysfunction isan effective treatment, and have good safety; simastatin and atorvastatin are effective; nicergolinecan improve cognitive functions in vascular dementia patient. At present, there is no evidence thatantiplatelet agents and antihypertensive drugs have positive treatment function.

Key words: Dementia; vascular; Cholinesterase inhibitors; Memantine; Nimodipine; Nicergoline